Bm2t-Cyclosporin A

Base Information

Chemical Name:Bm2t-Cyclosporin A
CAS No.:114865-22-4
Molecular Formula:C₆₃H₁₁₃N₁₁O₁₂
Molecular Weight:1216.66
Hs Code.:
Mol file:114865-22-4.mol

Synonyms:(MeBm(2)t)(1)-CsA;(MeBm2t)-CsA;4-(2-butenyl)-4,4,N-trimethyl-threonine(1)-cyclosporin A;4-(2-butenyl)-4,4,N-trimethyl-Tyr(1)-cyclosporin A;cyclosporin A, 4-(2-butenyl)-4,4,N-trimethylthreonine(1)-;MeBm(2)t1-CsA;N-methyl-4-((E)-2-butenyl)-4,4-dimethylthreonine cyclosporin A

Suppliers and Price of Bm2t-Cyclosporin A

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 0 raw suppliers

Chemical Property of Bm2t-Cyclosporin A

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Melting Point:134-137 °C
Boiling Point:1294.9°Cat760mmHg
PKA:13.32±0.70(Predicted)
Flash Point:736.9°C
PSA：292.76000
Density:1.014g/cm³
LogP:4.32800
XLogP3:7.9
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:12
Rotatable Bond Count:15
Exact Mass:1215.85701808
Heavy Atom Count:86
Complexity:2370

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC1C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1)C(C(C)(C)CC=CC)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C
Isomeric SMILES:CC[C@H]1C(=O)N(CC(=O)N([C@H](C(=O)N[C@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N(C(C(=O)N1)[C@@H](C(C)(C)C/C=C/C)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C

Technology Process of Bm2t-Cyclosporin A

There total 1 articles about Bm2t-Cyclosporin A which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 124562-21-6
<(9-fluorenylmethyl)oxycarbonyl>-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl<(2S,3R,6E)-4,4-dimethyl-3-hydroxy-2-(methylamino)-6-octenoyl>-L-2-aminobutyryl-sarcosyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanine benzyl ester

: 114865-22-4
cyclo-<<(2S,3R,6E)-4,4-dimethyl-3-hydroxy-2-(methylamino)-6-octenoyl>-L-2-aminobutyryl-sarcosyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl>

Guidance literature:: With dmap; sodium hydroxide; (PrPO₂)3; Yield given. Multistep reaction; 1.) EtOH, 0 deg C, 5.5 h, 2.) CH₂Cl₂, RT, 36 h;
DOI:10.1021/jm00165a018