(2R,3R)-3-<(1R)-3-<(tert-butyldiphenylsilyl)oxy>-1-methylpropyl>-2-methylcyclopentanone

Base Information

Chemical Name:(2R,3R)-3-<(1R)-3-<(tert-butyldiphenylsilyl)oxy>-1-methylpropyl>-2-methylcyclopentanone
CAS No.:146433-99-0
Molecular Formula:C₂₆H₃₆O₂Si
Molecular Weight:408.656
Hs Code.:

Synonyms:(2R,3R)-3-<(1R)-3-<(tert-butyldiphenylsilyl)oxy>-1-methylpropyl>-2-methylcyclopentanone

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Chemical Property of (2R,3R)-3-<(1R)-3-<(tert-butyldiphenylsilyl)oxy>-1-methylpropyl>-2-methylcyclopentanone

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Technology Process of (2R,3R)-3-<(1R)-3-<(tert-butyldiphenylsilyl)oxy>-1-methylpropyl>-2-methylcyclopentanone

There total 6 articles about (2R,3R)-3-<(1R)-3-<(tert-butyldiphenylsilyl)oxy>-1-methylpropyl>-2-methylcyclopentanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 146433-98-9
(2R,3R)-3-((R)-3-Hydroxy-1-methyl-propyl)-2-methyl-cyclopentanone

: 58479-61-1
tert-butylchlorodiphenylsilane

: 146433-99-0
(2R,3R)-3-<(1R)-3-<(tert-butyldiphenylsilyl)oxy>-1-methylpropyl>-2-methylcyclopentanone

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; for 1h; Ambient temperature;
DOI:10.1021/jo00058a032

Reference yield:

: 131336-04-4
(2R,3R)-3-<(1R)-2-(methoxycarbonyl)-1-methylethyl>-2-methylcyclopentanone

: 146433-99-0
(2R,3R)-3-<(1R)-3-<(tert-butyldiphenylsilyl)oxy>-1-methylpropyl>-2-methylcyclopentanone

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / LiAlH₄ / diethyl ether / 0.5 h / 0 °C

2: 76 percent / NaBrO₂ / H₂O; acetic acid / 7 h / Ambient temperature

3: 98 percent / imidazole / dimethylformamide / 1 h / Ambient temperature

With 1H-imidazole; lithium aluminium tetrahydride; sodium bromite; In diethyl ether; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jo00058a032

Reference yield:

: 131432-95-6
(1S,2R,3S,4S)-3-Methyl-6-oxo-bicyclo[2.2.1]heptane-2-carboxylic acid

: 146433-99-0
(2R,3R)-3-<(1R)-3-<(tert-butyldiphenylsilyl)oxy>-1-methylpropyl>-2-methylcyclopentanone

Guidance literature:: Multi-step reaction with 6 steps

1: 1) LDA / 1) THF, hexane, a) -20 deg C to room temperature, b) room temperature, 30 min, 2a) 0 deg C, 20 min, b) room temperature, 1.5 h

2: p-toluenesulfonic acid / 2 h / Heating

3: 74 percent / Li, naphthalene / tetrahydrofuran / 0.5 h / -60 °C

4: 100 percent / LiAlH₄ / diethyl ether / 0.5 h / 0 °C

5: 76 percent / NaBrO₂ / H₂O; acetic acid / 7 h / Ambient temperature

6: 98 percent / imidazole / dimethylformamide / 1 h / Ambient temperature

With 1H-imidazole; lithium aluminium tetrahydride; sodium bromite; naphthalene; lithium; toluene-4-sulfonic acid; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jo00058a032