(3aR,7aR,7bR,8aR)-7b-(2-methoxyphenyl)decahydro-3b,4a-diazadicyclopenta[a,e]pentalene

Base Information

Chemical Name:(3aR,7aR,7bR,8aR)-7b-(2-methoxyphenyl)decahydro-3b,4a-diazadicyclopenta[a,e]pentalene
CAS No.:431887-43-3
Molecular Formula:C₁₉H₂₆N₂O
Molecular Weight:298.428
Hs Code.:

Synonyms:(3aR,7aR,7bR,8aR)-7b-(2-methoxyphenyl)decahydro-3b,4a-diazadicyclopenta[a,e]pentalene

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Chemical Property of (3aR,7aR,7bR,8aR)-7b-(2-methoxyphenyl)decahydro-3b,4a-diazadicyclopenta[a,e]pentalene

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Technology Process of (3aR,7aR,7bR,8aR)-7b-(2-methoxyphenyl)decahydro-3b,4a-diazadicyclopenta[a,e]pentalene

There total 4 articles about (3aR,7aR,7bR,8aR)-7b-(2-methoxyphenyl)decahydro-3b,4a-diazadicyclopenta[a,e]pentalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 431887-39-7
(3aR,7aR,7bR,8aR)-7b-(2-methoxyphenyl)decahydro-3b,4a-diazadicyclopenta[a,e]pentalen-4-one

: 431887-43-3
(3aR,7aR,7bR,8aR)-7b-(2-methoxyphenyl)decahydro-3b,4a-diazadicyclopenta[a,e]pentalene

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 12h; Heating;

Reference yield:

: 349558-27-6
(all-R)-N-(tert-Butyloxycarbonyl)-2-azabicyclo[3.3.0]octan-3-one

: 431887-43-3
(3aR,7aR,7bR,8aR)-7b-(2-methoxyphenyl)decahydro-3b,4a-diazadicyclopenta[a,e]pentalene

Guidance literature:: Multi-step reaction with 4 steps

1.1: 64 percent / Mg / tetrahydrofuran / 20 °C

2.1: TFA / CH₂Cl₂ / 3 h / 0 - 20 °C

2.2: 80 percent / NaOH / CH₂Cl₂; H₂O / 0 °C

3.1: 42 percent / sec-BuLi; (-)-sparteine / cyclohexane; diethyl ether / 12 h / -78 °C

4.1: 86 percent / LiAlH₄ / tetrahydrofuran / 12 h / Heating

With lithium aluminium tetrahydride; sec.-butyllithium; magnesium; trifluoroacetic acid; (-)-sparteine; In tetrahydrofuran; diethyl ether; dichloromethane; cyclohexane;

Reference yield:

: 431887-30-8
(all-R)-2-(2-methoxyphenyl)-3,3a,4,5,6,6a-hexahydrocyclopenta[b]pyrrole

: 431887-43-3
(3aR,7aR,7bR,8aR)-7b-(2-methoxyphenyl)decahydro-3b,4a-diazadicyclopenta[a,e]pentalene

Guidance literature:: Multi-step reaction with 2 steps

1: 42 percent / sec-BuLi; (-)-sparteine / cyclohexane; diethyl ether / 12 h / -78 °C

2: 86 percent / LiAlH₄ / tetrahydrofuran / 12 h / Heating

With lithium aluminium tetrahydride; sec.-butyllithium; (-)-sparteine; In tetrahydrofuran; diethyl ether; cyclohexane;