(1R,3R,4R,7S)-7-benzyloxy-5-tert-butoxycarbonyl-1-hydroxymethyl-3-(adenin-9-yl)-2-oxa-5-azabicyclo[2.2.1]heptane

Base Information

Chemical Name:(1R,3R,4R,7S)-7-benzyloxy-5-tert-butoxycarbonyl-1-hydroxymethyl-3-(adenin-9-yl)-2-oxa-5-azabicyclo[2.2.1]heptane
CAS No.:946530-65-0
Molecular Formula:C₂₃H₂₈N₆O₅
Molecular Weight:468.513
Hs Code.:

Synonyms:(1R,3R,4R,7S)-7-benzyloxy-5-tert-butoxycarbonyl-1-hydroxymethyl-3-(adenin-9-yl)-2-oxa-5-azabicyclo[2.2.1]heptane

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Chemical Property of (1R,3R,4R,7S)-7-benzyloxy-5-tert-butoxycarbonyl-1-hydroxymethyl-3-(adenin-9-yl)-2-oxa-5-azabicyclo[2.2.1]heptane

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Technology Process of (1R,3R,4R,7S)-7-benzyloxy-5-tert-butoxycarbonyl-1-hydroxymethyl-3-(adenin-9-yl)-2-oxa-5-azabicyclo[2.2.1]heptane

There total 2 articles about (1R,3R,4R,7S)-7-benzyloxy-5-tert-butoxycarbonyl-1-hydroxymethyl-3-(adenin-9-yl)-2-oxa-5-azabicyclo[2.2.1]heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1001189-01-0
C₃₇H₃₆N₆O₇

: 946530-65-0
(1R,3R,4R,7S)-7-benzyloxy-5-tert-butoxycarbonyl-1-hydroxymethyl-3-(adenin-9-yl)-2-oxa-5-azabicyclo[2.2.1]heptane

Guidance literature:: With ammonia; In methanol; at 20 ℃; for 16h;

Reference yield:

: 946530-51-4
C₃₁H₃₄N₆O₈S

: 946530-65-0
(1R,3R,4R,7S)-7-benzyloxy-5-tert-butoxycarbonyl-1-hydroxymethyl-3-(adenin-9-yl)-2-oxa-5-azabicyclo[2.2.1]heptane

Guidance literature:: C₃₁H₃₄N₆O₈S; With sodium phenyl-methanolate; In dimethyl sulfoxide; at 90 ℃; for 2h;

With ammonia; In methanol; at 20 ℃; for 16h; Further stages.;
DOI:10.1016/j.bmc.2007.05.056

Reference yield: 30.0%

: 946530-65-0
(1R,3R,4R,7S)-7-benzyloxy-5-tert-butoxycarbonyl-1-hydroxymethyl-3-(adenin-9-yl)-2-oxa-5-azabicyclo[2.2.1]heptane

: 49617-83-6
m-Iodobenzyl bromide

: (1R,3R,4R,7S)-7-benzyloxy-5-tert-butoxycarbonyl-1-hydroxymethyl-3-(N⁶-(3-iodobenzyl)adenin-9-yl)-2-oxa-5-azabicyclo[2.2.1]heptane

Guidance literature:: (1R,3R,4R,7S)-7-benzyloxy-5-tert-butoxycarbonyl-1-hydroxymethyl-3-(adenin-9-yl)-2-oxa-5-azabicyclo[2.2.1]heptane; m-Iodobenzyl bromide; In N,N-dimethyl-formamide; at 70 ℃; for 32h;

With ammonium hydroxide; In methanol; for 16h; Further stages.;
DOI:10.1016/j.bmc.2007.05.056