methyl 3-benzyl-2,3,3a,4,5,7-hexahydro-4-[2-(tert-butyldimethylsiloxymethyl)pentyl]-1H-pyrrolo(2,3-d)carbazole-6-carboxylate

Base Information

Chemical Name:methyl 3-benzyl-2,3,3a,4,5,7-hexahydro-4-[2-(tert-butyldimethylsiloxymethyl)pentyl]-1H-pyrrolo(2,3-d)carbazole-6-carboxylate
CAS No.:126606-28-8
Molecular Formula:C₃₅H₅₀N₂O₃Si
Molecular Weight:574.879
Hs Code.:

Synonyms:methyl 3-benzyl-2,3,3a,4,5,7-hexahydro-4-[2-(tert-butyldimethylsiloxymethyl)pentyl]-1H-pyrrolo(2,3-d)carbazole-6-carboxylate

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Chemical Property of methyl 3-benzyl-2,3,3a,4,5,7-hexahydro-4-[2-(tert-butyldimethylsiloxymethyl)pentyl]-1H-pyrrolo(2,3-d)carbazole-6-carboxylate

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Technology Process of methyl 3-benzyl-2,3,3a,4,5,7-hexahydro-4-[2-(tert-butyldimethylsiloxymethyl)pentyl]-1H-pyrrolo(2,3-d)carbazole-6-carboxylate

There total 8 articles about methyl 3-benzyl-2,3,3a,4,5,7-hexahydro-4-[2-(tert-butyldimethylsiloxymethyl)pentyl]-1H-pyrrolo(2,3-d)carbazole-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-benzyl-1,2,4,6-tetrahydro-11-[3-(tert-butyldimethylsiloxymethyl)hexyl]-3,10b-methanoazepino-5-methoxycarbonyl-(4,5-b)indolium bromide

: 126606-28-8
methyl 3-benzyl-2,3,3a,4,5,7-hexahydro-4-[2-(tert-butyldimethylsiloxymethyl)pentyl]-1H-pyrrolo(2,3-d)carbazole-6-carboxylate

Guidance literature:: With diisopropylamine; In methanol; for 3h; Heating;
DOI:10.1039/b209990j

Reference yield:

: 110-62-3
pentanal

: 126606-28-8
methyl 3-benzyl-2,3,3a,4,5,7-hexahydro-4-[2-(tert-butyldimethylsiloxymethyl)pentyl]-1H-pyrrolo(2,3-d)carbazole-6-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: 85.7 percent / potassium carbonate / 64 h / 0 °C

2.1: dioxane / 16 h / Heating

2.2: 33 percent / H₂O / 8 h / Heating

3.1: NaBH₄ / methanol / 2 h / 3 - 5 °C

4.1: CH₂Cl₂ / 0.17 h / 3 - 4 °C

4.2: 68.22 g / 4-dimethylaminopyridine / CH₂Cl₂ / 66 h / 20 °C

5.1: DIBAL-H / toluene / 3.25 h / -70 °C

6.1: methanol / 19 h / 20 °C

7.1: tetrahydrofuran / 19 h / 20 °C

8.1: 16.48 g / diisopropylamine / methanol / 3 h / Heating

With sodium tetrahydroborate; diisobutylaluminium hydride; potassium carbonate; diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; toluene;
DOI:10.1039/b209990j

Reference yield:

: 126554-00-5
N-[1-(E)-penten-1-yl]pyrrolidine

: 126606-28-8
methyl 3-benzyl-2,3,3a,4,5,7-hexahydro-4-[2-(tert-butyldimethylsiloxymethyl)pentyl]-1H-pyrrolo(2,3-d)carbazole-6-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: dioxane / 16 h / Heating

1.2: 33 percent / H₂O / 8 h / Heating

2.1: NaBH₄ / methanol / 2 h / 3 - 5 °C

3.1: CH₂Cl₂ / 0.17 h / 3 - 4 °C

3.2: 68.22 g / 4-dimethylaminopyridine / CH₂Cl₂ / 66 h / 20 °C

4.1: DIBAL-H / toluene / 3.25 h / -70 °C

5.1: methanol / 19 h / 20 °C

6.1: tetrahydrofuran / 19 h / 20 °C

7.1: 16.48 g / diisopropylamine / methanol / 3 h / Heating

With sodium tetrahydroborate; diisobutylaluminium hydride; diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; toluene;
DOI:10.1039/b209990j