Ranolazine dihydrochloride

Base Information

• Chemical Name: Ranolazine dihydrochloride
• CAS No.: 95635-56-6
• Molecular Formula: C24H33N3O4^.2(HCl)
• Molecular Weight: 500.46
• Hs Code.: 29335990
• Mol file: 95635-56-6.mol

Synonyms:1-Piperazineacetamide,N-(2,6-dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-,dihydrochloride (9CI);RS 43285;RS43285-193;Ranolazine hydrochloride;

Chemical Property of Ranolazine dihydrochloride

Chemical Property:

• Appearance/Colour: White crystalline powder
• Vapor Pressure: 1.94E-16mmHg at 25°C
• Melting Point: 222-229.5 °C(lit.)
• Boiling Point: 624.1 °C at 760 mmHg
• Flash Point: 331.2 °C
• PSA: 74.27000
• LogP: 3.86080
• Storage Temp.: Desiccate at RT
• Solubility.: H2O: 10 mg/mL, soluble

Purity/Quality:

99% ^*data from raw suppliers

Ranolazine dihydrochloride ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Description: Ranolazine is a piperazine derivative with cardioprotective activity. It reduces the late sodium current (INa) in mouse myocytes expressing the long QT syndrome 3 mutant sodium channel DKPQ, ventricular myocytes isolated from a canine model of heart failure, guinea pig ventricular myocytes exposed to hydrogen peroxide or anemone toxin-II, and HEK293 cells expressing human Nav1.5 channels (IC50s = 5.9-15 μM) as well as the late potassium current (IKr) in canine ventricular myocytes and HEK293 cells (IC50s = 11.5 and 14.4 μM, respectively). Ranolazine also inhibits radioligand binding to α1-, β1-, and β2-adrenergic receptors (Kis = 8.2-19.5, 1.4-8.6, and 0.5-14.8 μM, respectively). In vivo, ranolazine (480 μg/kg per min) reduces clofilium-induced prolongation of the QTc interval and Torsade de Pointes (TdP) in rabbits. Ranolazine also reduces interstitial collagen deposition as well as atrial natriuretic peptide (ANP; Item Nos. 24539 | 24276), connective tissue growth factor (CTGF), brain natriuretic peptide (BNP; ), and matrix metalloproteinase-2 (MMP-2) mRNA levels, and prevents left ventricular dilation in a mouse model of cardiotoxicity induced by doxorubicin .
• Uses: treatment of angina and congestive heart failure Ranolazine Dihydrochloride is an anti-ischemic agent which modulates myocardial metabolism. Antianginal. Anti-ischemic agent which modulates myocardial metabolism. Antianginal