(S)-2-( 6-(4-borono-3-fluorobenzyloxy)benzo[d]thiazol-2-yl)-4,5-dihydrothiazole-4-carboxylic acid

Base Information

• Chemical Name: (S)-2-( 6-(4-borono-3-fluorobenzyloxy)benzo[d]thiazol-2-yl)-4,5-dihydrothiazole-4-carboxylic acid
• CAS No.: 1622311-98-1
• Molecular Formula: C₁₈H₁₄BFN₂O₅S₂
• Molecular Weight: 432.261
• Mol file: 1622311-98-1.mol

Synonyms:(S)-2-( 6-(4-borono-3-fluorobenzyloxy)benzo[d]thiazol-2-yl)-4,5-dihydrothiazole-4-carboxylic acid

Chemical Property of (S)-2-( 6-(4-borono-3-fluorobenzyloxy)benzo[d]thiazol-2-yl)-4,5-dihydrothiazole-4-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-( 6-(4-borono-3-fluorobenzyloxy)benzo[d]thiazol-2-yl)-4,5-dihydrothiazole-4-carboxylic acid

There total 3 articles about (S)-2-( 6-(4-borono-3-fluorobenzyloxy)benzo[d]thiazol-2-yl)-4,5-dihydrothiazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

6-((3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)oxy)benzo[d]thiazole-2-carbonitrile + D-cysteine hydrochloride (32443-99-5) → (S)-2-( 6-(4-borono-3-fluorobenzyloxy)benzo[d]thiazol-2-yl)-4,5-dihydrothiazole-4-carboxylic acid (1622311-98-1)

Guidance literature:

6-((3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)oxy)benzo[d]thiazole-2-carbonitrile; D-cysteine hydrochloride; With potassium carbonate; In methanol; dichloromethane; water; Inert atmosphere;

With hydrogenchloride; water; Inert atmosphere;

Reference yield:

2-(4-(bromomethyl)-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1029439-49-3) → (S)-2-( 6-(4-borono-3-fluorobenzyloxy)benzo[d]thiazol-2-yl)-4,5-dihydrothiazole-4-carboxylic acid (1622311-98-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: cesium chloride / N,N-dimethyl-formamide / 60 °C

2.1: potassium carbonate / water; dichloromethane; methanol / Inert atmosphere

2.2: Inert atmosphere

With cesium chloride; potassium carbonate; In methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

2-cyano-6-hydroxybenzothiazole (939-69-5) → (S)-2-( 6-(4-borono-3-fluorobenzyloxy)benzo[d]thiazol-2-yl)-4,5-dihydrothiazole-4-carboxylic acid (1622311-98-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: cesium chloride / N,N-dimethyl-formamide / 60 °C

2.1: potassium carbonate / water; dichloromethane; methanol / Inert atmosphere

2.2: Inert atmosphere

With cesium chloride; potassium carbonate; In methanol; dichloromethane; water; N,N-dimethyl-formamide;

upstream raw materials:

D-cysteine hydrochloride

2-(4-(bromomethyl)-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

2-cyano-6-hydroxybenzothiazole

Downstream raw materials:

D-luciferin