(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl 4-(2-fluoroethyl)benzoylformate

Base Information

Chemical Name:(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl 4-(2-fluoroethyl)benzoylformate
CAS No.:153993-92-1
Molecular Formula:C₂₆H₃₁FO₃
Molecular Weight:410.529
Hs Code.:

Synonyms:(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl 4-(2-fluoroethyl)benzoylformate

Suppliers and Price of (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl 4-(2-fluoroethyl)benzoylformate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl 4-(2-fluoroethyl)benzoylformate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl 4-(2-fluoroethyl)benzoylformate

There total 6 articles about (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl 4-(2-fluoroethyl)benzoylformate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 65253-04-5
(-)-8-phenylmenthol

: 4-(2-fluoroethyl)benzoylformic acid chloride

: 153993-92-1
(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl 4-(2-fluoroethyl)benzoylformate

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 1h; Yield given;
DOI:10.1016/S0957-4166(00)80069-5

Reference yield:

: 4654-39-1
4-bromophenethanol

: 153993-92-1
(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl 4-(2-fluoroethyl)benzoylformate

Guidance literature:: Multi-step reaction with 6 steps

1: pyridine / CH₂Cl₂ / 2 h / 0 °C

2: Me₄NFHF / acetonitrile / 1 h / Ambient temperature

3: 1.) Mg, I₂ / 1.) THF, sonication, 2.) THF, a.) -78 deg C, 40 min, b.) 1 h

4: 2N aq. NaOH / 0.5 h

5: Cl₂CHOCH₃ / CH₂Cl₂ / 2 h / Heating

6: Et₃N / CH₂Cl₂ / 1 h / 0 °C

With pyridine; sodium hydroxide; Dichloromethyl methyl ether; iodine; magnesium; tetramethylammonium hydrogen difluoride; triethylamine; In dichloromethane; acetonitrile;
DOI:10.1016/S0957-4166(00)80069-5

Reference yield:

: 55153-09-8
1-bromo-4-(2-fluoroethyl)benzene

: 153993-92-1
(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl 4-(2-fluoroethyl)benzoylformate

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) Mg, I₂ / 1.) THF, sonication, 2.) THF, a.) -78 deg C, 40 min, b.) 1 h

2: 2N aq. NaOH / 0.5 h

3: Cl₂CHOCH₃ / CH₂Cl₂ / 2 h / Heating

4: Et₃N / CH₂Cl₂ / 1 h / 0 °C

With sodium hydroxide; Dichloromethyl methyl ether; iodine; magnesium; triethylamine; In dichloromethane;
DOI:10.1016/S0957-4166(00)80069-5