4-(4-nitrobenzyloxycarbonylamino)-2,2-difluoro-3-hydroxy-5-(4-benzyloxyphenyl)pentanamide

Base Information

Chemical Name:4-(4-nitrobenzyloxycarbonylamino)-2,2-difluoro-3-hydroxy-5-(4-benzyloxyphenyl)pentanamide
CAS No.:173918-51-9
Molecular Formula:C₂₆H₂₅F₂N₃O₇
Molecular Weight:529.497
Hs Code.:

Synonyms:4-(4-nitrobenzyloxycarbonylamino)-2,2-difluoro-3-hydroxy-5-(4-benzyloxyphenyl)pentanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(4-nitrobenzyloxycarbonylamino)-2,2-difluoro-3-hydroxy-5-(4-benzyloxyphenyl)pentanamide

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Technology Process of 4-(4-nitrobenzyloxycarbonylamino)-2,2-difluoro-3-hydroxy-5-(4-benzyloxyphenyl)pentanamide

There total 3 articles about 4-(4-nitrobenzyloxycarbonylamino)-2,2-difluoro-3-hydroxy-5-(4-benzyloxyphenyl)pentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 173918-50-8
4-(4-nitrobenzyloxycarbonylamino)-2,2-difluoro-3-hydroxy-5-(4-benzyloxyphenyl) pentanoic acid ethyl ester

: 173918-51-9
4-(4-nitrobenzyloxycarbonylamino)-2,2-difluoro-3-hydroxy-5-(4-benzyloxyphenyl)pentanamide

Guidance literature:: With ammonia; In diethyl ether; at -78 ℃;
DOI:10.1016/0040-4020(95)00896-G

Reference yield:

: 173918-49-5
(R,S)-N-(4-nitrobenzyloxycarbonyl)-O-benzyl-tyrosinal

: 173918-51-9
4-(4-nitrobenzyloxycarbonylamino)-2,2-difluoro-3-hydroxy-5-(4-benzyloxyphenyl)pentanamide

Guidance literature:: Multi-step reaction with 2 steps

1: 46 percent / zinc / tetrahydrofuran / reflux; rt, 15 h

2: 57 percent / ammonia gas / diethyl ether / -78 °C

With ammonia; zinc; In tetrahydrofuran; diethyl ether;
DOI:10.1016/0040-4020(95)00896-G

Reference yield:

: (R,S)-N-(4-nitrobenzyloxycarbonyl)-O-benzyl-tyrosine methyl ester

: 173918-51-9
4-(4-nitrobenzyloxycarbonylamino)-2,2-difluoro-3-hydroxy-5-(4-benzyloxyphenyl)pentanamide

Guidance literature:: Multi-step reaction with 3 steps

1: 51 percent / ddisobutylaluminium hydride / diethyl ether; toluene; hexane / 0.17 h / -78 °C

2: 46 percent / zinc / tetrahydrofuran / reflux; rt, 15 h

3: 57 percent / ammonia gas / diethyl ether / -78 °C

With ammonia; diisobutylaluminium hydride; zinc; In tetrahydrofuran; diethyl ether; hexane; toluene;
DOI:10.1016/0040-4020(95)00896-G