7-(3-(4-(3-((1,2,3,4-tetrahydroacridin-9-yl)amino)propyl)piperazin-1-yl)propoxy)-2-(p-tolyl)-4H-chromen-4-one

Base Information

• Chemical Name: 7-(3-(4-(3-((1,2,3,4-tetrahydroacridin-9-yl)amino)propyl)piperazin-1-yl)propoxy)-2-(p-tolyl)-4H-chromen-4-one
• CAS No.: 1489103-07-2
• Molecular Formula: C₃₉H₄₄N₄O₃
• Molecular Weight: 616.803

Synonyms:7-(3-(4-(3-((1,2,3,4-tetrahydroacridin-9-yl)amino)propyl)piperazin-1-yl)propoxy)-2-(p-tolyl)-4H-chromen-4-one

Chemical Property of 7-(3-(4-(3-((1,2,3,4-tetrahydroacridin-9-yl)amino)propyl)piperazin-1-yl)propoxy)-2-(p-tolyl)-4H-chromen-4-one

Chemical Property:

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Technology Process of 7-(3-(4-(3-((1,2,3,4-tetrahydroacridin-9-yl)amino)propyl)piperazin-1-yl)propoxy)-2-(p-tolyl)-4H-chromen-4-one

There total 9 articles about 7-(3-(4-(3-((1,2,3,4-tetrahydroacridin-9-yl)amino)propyl)piperazin-1-yl)propoxy)-2-(p-tolyl)-4H-chromen-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.5%

7-(3-bromopropoxy)-2-(p-tolyl)-4H-chromen-4-one (191936-15-9) + N-(3-(piperazin-1-yl)propyl)-1,2,3,4-tetrahydroacridin-9-amine (1489102-49-9) → 7-(3-(4-(3-((1,2,3,4-tetrahydroacridin-9-yl)amino)propyl)piperazin-1-yl)propoxy)-2-(p-tolyl)-4H-chromen-4-one (1489103-07-2)

Guidance literature:

With potassium carbonate; In acetonitrile; for 8h; Reflux;

DOI:10.1016/j.ejmech.2013.09.024

Reference yield:

2',4'-dihydroxy-4-acetophenone (89-84-9) → 7-(3-(4-(3-((1,2,3,4-tetrahydroacridin-9-yl)amino)propyl)piperazin-1-yl)propoxy)-2-(p-tolyl)-4H-chromen-4-one (1489103-07-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 3.25 h / -78 °C / Inert atmosphere

1.2: 5.17 h / -78 - 20 °C / Inert atmosphere

2.1: potassium carbonate / acetone / 4 h / Reflux

3.1: potassium carbonate / acetonitrile / 8 h / Reflux

With potassium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; acetone; acetonitrile;

DOI:10.1016/j.ejmech.2013.09.024

Reference yield:

4-methyl-benzoyl chloride (874-60-2) → 7-(3-(4-(3-((1,2,3,4-tetrahydroacridin-9-yl)amino)propyl)piperazin-1-yl)propoxy)-2-(p-tolyl)-4H-chromen-4-one (1489103-07-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 3.25 h / -78 °C / Inert atmosphere

1.2: 5.17 h / -78 - 20 °C / Inert atmosphere

2.1: potassium carbonate / acetone / 4 h / Reflux

3.1: potassium carbonate / acetonitrile / 8 h / Reflux

With potassium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; acetone; acetonitrile;

DOI:10.1016/j.ejmech.2013.09.024

upstream raw materials:

2',4'-dihydroxy-4-acetophenone

4-methyl-benzoyl chloride

4'-Methyl-7-hydroxyflavone

anthranilic acid

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