4-(1,3-dimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)-benzenesulphonyl chloride

Base Information

• Chemical Name: 4-(1,3-dimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)-benzenesulphonyl chloride
• CAS No.: 612095-43-9
• Molecular Formula: C₁₄H₁₂ClN₃O₄S
• Molecular Weight: 353.786

Synonyms:4-(1,3-dimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)-benzenesulphonyl chloride

Chemical Property of 4-(1,3-dimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)-benzenesulphonyl chloride

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Technology Process of 4-(1,3-dimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)-benzenesulphonyl chloride

There total 1 articles about 4-(1,3-dimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)-benzenesulphonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1,3-dimethyl-6-phenylpyrrolo<3,2-d>pyrimidine-2,4(1H,3H)-dione (59119-44-7) → 4-(1,3-dimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)-benzenesulphonyl chloride (612095-43-9)

Guidance literature:

With chlorosulfonic acid; thionyl chloride; at 0 - 20 ℃; for 2.5h;

Reference yield: 47.0%

4-(1,3-dimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)-benzenesulphonyl chloride (612095-43-9) + 1-phenylmethylpiperazine (2759-28-6) → 6-[4-(4-benzylpiperazine-1-sulphonyl)phenyl]-1,3-dimethyl-1,5-dihydropyrrolo[3,2-d]pyrimidine-2,4-dione

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

2-aminopyridine (504-29-0) + 4-(1,3-dimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)-benzenesulphonyl chloride (612095-43-9) → 4-(1,3-dimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)-N-pyridin-2-ylbenzenesulphonamide

Guidance literature:

With triethylamine; In dichloromethane; at 25 ℃;

DOI:10.1016/j.bmcl.2006.04.074

upstream raw materials:

1,3-dimethyl-6-phenylpyrrolo<3,2-d>pyrimidine-2,4(1H,3H)-dione

Downstream raw materials:

C₂₁H₂₁N₅O₅S

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