ethyl 3-({2-[(R)-2-tert-butoxycarbonylamino-2-methyl-3-phenylpropanoyl]hydrazino}carbonyl)-5-(1-cyanocyclopentyl)benzoate

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Chemical Name:ethyl 3-({2-[(R)-2-tert-butoxycarbonylamino-2-methyl-3-phenylpropanoyl]hydrazino}carbonyl)-5-(1-cyanocyclopentyl)benzoate
CAS No.:868286-41-3
Molecular Formula:C₃₁H₃₈N₄O₆
Molecular Weight:562.666
Hs Code.:

Synonyms:ethyl 3-({2-[(R)-2-tert-butoxycarbonylamino-2-methyl-3-phenylpropanoyl]hydrazino}carbonyl)-5-(1-cyanocyclopentyl)benzoate

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Chemical Property of ethyl 3-({2-[(R)-2-tert-butoxycarbonylamino-2-methyl-3-phenylpropanoyl]hydrazino}carbonyl)-5-(1-cyanocyclopentyl)benzoate

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Technology Process of ethyl 3-({2-[(R)-2-tert-butoxycarbonylamino-2-methyl-3-phenylpropanoyl]hydrazino}carbonyl)-5-(1-cyanocyclopentyl)benzoate

There total 7 articles about ethyl 3-({2-[(R)-2-tert-butoxycarbonylamino-2-methyl-3-phenylpropanoyl]hydrazino}carbonyl)-5-(1-cyanocyclopentyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 853304-00-4
3-(ethoxycarbonyl)-5-(1-cyanocyclopentyl)benzoic acid

: 868286-25-3
(R)-tert-butyl (1-hydrazinyl-2-methyl-1-oxo-3-phenylpropan-2-yl)carbamate

: 868286-41-3
ethyl 3-({2-[(R)-2-tert-butoxycarbonylamino-2-methyl-3-phenylpropanoyl]hydrazino}carbonyl)-5-(1-cyanocyclopentyl)benzoate

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 853303-98-7
diethyl 5-(cyanomethyl)-benzene-1,3-dioate

: 868286-41-3
ethyl 3-({2-[(R)-2-tert-butoxycarbonylamino-2-methyl-3-phenylpropanoyl]hydrazino}carbonyl)-5-(1-cyanocyclopentyl)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hexamethylsilazane / tetrahydrofuran / 0.08 h / 20 °C

1.2: 0.75 h

2.1: sodium hydroxide; ethanol; water / tetrahydrofuran / 20 °C

3.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

With sodium hydroxide; ethanol; water; potassium hexamethylsilazane; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 868286-41-3
ethyl 3-({2-[(R)-2-tert-butoxycarbonylamino-2-methyl-3-phenylpropanoyl]hydrazino}carbonyl)-5-(1-cyanocyclopentyl)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / 1,4-dioxane; water / 14 h

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; hydrazine / acetonitrile / 20 °C

3: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

With sodium hydroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; hydrazine; In 1,4-dioxane; dichloromethane; water; acetonitrile;