2-(4-chloro-2-fluoro-5-nitro-phenyl)-4-(2-fluoro-ethyl)-5-methyl-2,4-dihydro-[1,2,4]triazol-3-one

Base Information

• Chemical Name: 2-(4-chloro-2-fluoro-5-nitro-phenyl)-4-(2-fluoro-ethyl)-5-methyl-2,4-dihydro-[1,2,4]triazol-3-one
• CAS No.: 220062-96-4
• Molecular Formula: C₁₁H₉ClF₂N₄O₃
• Molecular Weight: 318.667

Synonyms:2-(4-chloro-2-fluoro-5-nitro-phenyl)-4-(2-fluoro-ethyl)-5-methyl-2,4-dihydro-[1,2,4]triazol-3-one

Chemical Property of 2-(4-chloro-2-fluoro-5-nitro-phenyl)-4-(2-fluoro-ethyl)-5-methyl-2,4-dihydro-[1,2,4]triazol-3-one

Chemical Property:

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Technology Process of 2-(4-chloro-2-fluoro-5-nitro-phenyl)-4-(2-fluoro-ethyl)-5-methyl-2,4-dihydro-[1,2,4]triazol-3-one

There total 2 articles about 2-(4-chloro-2-fluoro-5-nitro-phenyl)-4-(2-fluoro-ethyl)-5-methyl-2,4-dihydro-[1,2,4]triazol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-chloro-2-fluoro-phenyl)-4-(2-fluoro-ethyl)-5-methyl-2,4-dihydro-[1,2,4]triazol-3-one (220062-95-3) → 2-(4-chloro-2-fluoro-5-nitro-phenyl)-4-(2-fluoro-ethyl)-5-methyl-2,4-dihydro-[1,2,4]triazol-3-one (220062-96-4)

Guidance literature:

With sulfuric acid; nitric acid; at 10 ℃; for 82h;

DOI:10.1016/S0040-4039(98)02111-X

Reference yield:

4,5-dihydro-1-(4-chloro-2-fluorophenyl)-3-methyl-5-oxo-1H-1,2,4-triazole (111992-04-2) → 2-(4-chloro-2-fluoro-5-nitro-phenyl)-4-(2-fluoro-ethyl)-5-methyl-2,4-dihydro-[1,2,4]triazol-3-one (220062-96-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / K₂CO₃, NaI / dimethylformamide / 4 h / 80 °C

2: HNO₃, H₂SO₄ / 82 h / 10 °C

With sulfuric acid; nitric acid; potassium carbonate; sodium iodide; In N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(98)02111-X

Reference yield: 85.0%

2-(4-chloro-2-fluoro-5-nitro-phenyl)-4-(2-fluoro-ethyl)-5-methyl-2,4-dihydro-[1,2,4]triazol-3-one (220062-96-4) → 1-(4-chloro-2-fluoro-5-aminophenyl)-4-(2-fluoroethyl)-4,5-dihydro-3-methyl-1,2,4-triazolin-5(1H)-one (220062-97-5)

Guidance literature:

With hydrogen; platinum(IV) oxide;

DOI:10.1016/S0040-4039(98)02111-X

upstream raw materials:

2-(4-chloro-2-fluoro-phenyl)-4-(2-fluoro-ethyl)-5-methyl-2,4-dihydro-[1,2,4]triazol-3-one

4,5-dihydro-1-(4-chloro-2-fluorophenyl)-3-methyl-5-oxo-1H-1,2,4-triazole

Downstream raw materials:

1-(4-chloro-2-fluoro-5-aminophenyl)-4-(2-fluoroethyl)-4,5-dihydro-3-methyl-1,2,4-triazolin-5(1H)-one

N-[2-chloro-4-fluoro-5-(3-methyl-5-oxo-4-vinyl-4,5-dihydro-[1,2,4]triazol-1-yl)-phenyl]-N-methyl-methanesulfonamide

N-{2-chloro-4-fluoro-5-[4-(2-fluoro-ethyl)-3-methyl-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl]-phenyl}-methanesulfonamide

N-{2-chloro-4-fluoro-5-[4-(2-fluoro-ethyl)-3-methyl-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl]-phenyl}-N-methyl-methanesulfonamide

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