4-((S)-4-carboxy-2-{[6-(cyclohexanecarbonyl-amino)-2-phenyl-pyrimidine-4-carbonyl]-amino}-butyryl)-piperazine-1-carboxylic acid ethyl ester

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Chemical Name:4-((S)-4-carboxy-2-{[6-(cyclohexanecarbonyl-amino)-2-phenyl-pyrimidine-4-carbonyl]-amino}-butyryl)-piperazine-1-carboxylic acid ethyl ester
CAS No.:913950-41-1
Molecular Formula:C₃₀H₃₈N₆O₇
Molecular Weight:594.668
Hs Code.:

Synonyms:4-((S)-4-carboxy-2-{[6-(cyclohexanecarbonyl-amino)-2-phenyl-pyrimidine-4-carbonyl]-amino}-butyryl)-piperazine-1-carboxylic acid ethyl ester

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Chemical Property of 4-((S)-4-carboxy-2-{[6-(cyclohexanecarbonyl-amino)-2-phenyl-pyrimidine-4-carbonyl]-amino}-butyryl)-piperazine-1-carboxylic acid ethyl ester

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Technology Process of 4-((S)-4-carboxy-2-{[6-(cyclohexanecarbonyl-amino)-2-phenyl-pyrimidine-4-carbonyl]-amino}-butyryl)-piperazine-1-carboxylic acid ethyl ester

There total 14 articles about 4-((S)-4-carboxy-2-{[6-(cyclohexanecarbonyl-amino)-2-phenyl-pyrimidine-4-carbonyl]-amino}-butyryl)-piperazine-1-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 913951-62-9
4-{(S)-2-[(6-amino-2-phenyl-pyrimidine-4-carbonyl)-amino]-4-tert-butoxycarbonyl-butyryl}-piperazine-1-carboxylic acid ethyl ester

: 2719-27-9
cyclohexanylcarbonyl chloride

: 913950-41-1
4-((S)-4-carboxy-2-{[6-(cyclohexanecarbonyl-amino)-2-phenyl-pyrimidine-4-carbonyl]-amino}-butyryl)-piperazine-1-carboxylic acid ethyl ester

Guidance literature:: 4-{(S)-2-[(6-amino-2-phenyl-pyrimidine-4-carbonyl)-amino]-4-tert-butoxycarbonyl-butyryl}-piperazine-1-carboxylic acid ethyl ester; cyclohexanylcarbonyl chloride; With pyridine; at 70 ℃;

With trifluoroacetic acid; at 20 ℃; for 3h;

Reference yield:

: C₃₄H₄₆N₆O₇

: 913950-41-1
4-((S)-4-carboxy-2-{[6-(cyclohexanecarbonyl-amino)-2-phenyl-pyrimidine-4-carbonyl]-amino}-butyryl)-piperazine-1-carboxylic acid ethyl ester

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmcl.2014.06.070

Reference yield:

: 120-43-4
4-ethoxycarbonylpiperazine

: 913950-41-1
4-((S)-4-carboxy-2-{[6-(cyclohexanecarbonyl-amino)-2-phenyl-pyrimidine-4-carbonyl]-amino}-butyryl)-piperazine-1-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane; tetrahydrofuran / 20 °C

2: palladium on activated charcoal; hydrogen / ethanol / 20 °C

3: triethylamine / acetonitrile / 0 - 20 °C

4: ammonia / methanol / 90 °C / Microwave irradiation; Sealed tube

5: pyridine / 70 °C

6: trifluoroacetic acid / dichloromethane / 20 °C

With pyridine; palladium on activated charcoal; ammonia; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane; acetonitrile;
DOI:10.1016/j.bmcl.2014.06.070