2-(R)-(tert-butyldimethylsilanoxy)-3-(4-triisopropylsilanyloxyphenyl)-propan-1-ol

Base Information

Chemical Name:2-(R)-(tert-butyldimethylsilanoxy)-3-(4-triisopropylsilanyloxyphenyl)-propan-1-ol
CAS No.:320748-79-6
Molecular Formula:C₂₄H₄₆O₃Si₂
Molecular Weight:438.798
Hs Code.:

Synonyms:2-(R)-(tert-butyldimethylsilanoxy)-3-(4-triisopropylsilanyloxyphenyl)-propan-1-ol

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Chemical Property of 2-(R)-(tert-butyldimethylsilanoxy)-3-(4-triisopropylsilanyloxyphenyl)-propan-1-ol

Chemical Property:

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Technology Process of 2-(R)-(tert-butyldimethylsilanoxy)-3-(4-triisopropylsilanyloxyphenyl)-propan-1-ol

There total 5 articles about 2-(R)-(tert-butyldimethylsilanoxy)-3-(4-triisopropylsilanyloxyphenyl)-propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1-[(R)-3-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-propyl]-4-triisopropylsilanyloxy-benzene

: 320748-79-6
2-(R)-(tert-butyldimethylsilanoxy)-3-(4-triisopropylsilanyloxyphenyl)-propan-1-ol

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; for 50h; under 2280.15 Torr;
DOI:10.1021/ol006759x

Reference yield:

: 106-41-2
4-bromo-phenol

: 320748-79-6
2-(R)-(tert-butyldimethylsilanoxy)-3-(4-triisopropylsilanyloxyphenyl)-propan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: 88 percent / imidazole / tetrahydrofuran / 36 h / 20 °C

2.1: t-BuLi / tetrahydrofuran; pentane / 0.17 h / -78 °C

2.2: 83 percent / CuBr*SMe₂; BF₃*OEt₂ / tetrahydrofuran; pentane / -45 - -20 °C

3.1: imidazole / CH₂Cl₂ / 11 h / 20 °C

4.1: 289 mg / H₂ / Pd/C / ethyl acetate / 50 h / 2280.15 Torr

With 1H-imidazole; hydrogen; tert.-butyl lithium; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; pentane;
DOI:10.1021/ol006759x

Reference yield:

: 13154-24-0
triisopropylsilyl chloride

: 320748-79-6
2-(R)-(tert-butyldimethylsilanoxy)-3-(4-triisopropylsilanyloxyphenyl)-propan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: 88 percent / imidazole / tetrahydrofuran / 36 h / 20 °C

2.1: t-BuLi / tetrahydrofuran; pentane / 0.17 h / -78 °C

2.2: 83 percent / CuBr*SMe₂; BF₃*OEt₂ / tetrahydrofuran; pentane / -45 - -20 °C

3.1: imidazole / CH₂Cl₂ / 11 h / 20 °C

4.1: 289 mg / H₂ / Pd/C / ethyl acetate / 50 h / 2280.15 Torr

With 1H-imidazole; hydrogen; tert.-butyl lithium; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; pentane;
DOI:10.1021/ol006759x