N-(3-acetamido-5-((tert-butyldimethylsilyloxy)methyl)phenyl)-3-(2-(diisopropylamino)acetamido)benzamide

Base Information

Chemical Name:N-(3-acetamido-5-((tert-butyldimethylsilyloxy)methyl)phenyl)-3-(2-(diisopropylamino)acetamido)benzamide
CAS No.:1357620-20-2
Molecular Formula:C₃₀H₄₆N₄O₄Si
Molecular Weight:554.805
Hs Code.:

Synonyms:N-(3-acetamido-5-((tert-butyldimethylsilyloxy)methyl)phenyl)-3-(2-(diisopropylamino)acetamido)benzamide

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Chemical Property of N-(3-acetamido-5-((tert-butyldimethylsilyloxy)methyl)phenyl)-3-(2-(diisopropylamino)acetamido)benzamide

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Technology Process of N-(3-acetamido-5-((tert-butyldimethylsilyloxy)methyl)phenyl)-3-(2-(diisopropylamino)acetamido)benzamide

There total 7 articles about N-(3-acetamido-5-((tert-butyldimethylsilyloxy)methyl)phenyl)-3-(2-(diisopropylamino)acetamido)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1018449-03-0
C₁₅H₂₆N₂O₂Si

: 1357620-04-2
3-(2-(diisopropylamino)acetamido)benzoic acid

: 1357620-20-2
N-(3-acetamido-5-((tert-butyldimethylsilyloxy)methyl)phenyl)-3-(2-(diisopropylamino)acetamido)benzamide

Guidance literature:: With dmap; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 20 ℃; for 20h; Inert atmosphere;
DOI:10.1016/j.tet.2011.12.030

Reference yield:

: 1357619-93-2
benzyl 3-(2-bromoacetamido) benzoate

: 1357620-20-2
N-(3-acetamido-5-((tert-butyldimethylsilyloxy)methyl)phenyl)-3-(2-(diisopropylamino)acetamido)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / Reflux

2: palladium 10% on activated carbon; hydrogen / methanol / 5 h / 20 °C / 760.05 Torr

3: dmap; benzotriazol-1-ol; dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 20 h / 20 °C / Inert atmosphere

With dmap; palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2011.12.030

Reference yield:

: 1357619-99-8
benzyl 3-(2-(diisopropylamino)acetamido)benzoate

: 1357620-20-2
N-(3-acetamido-5-((tert-butyldimethylsilyloxy)methyl)phenyl)-3-(2-(diisopropylamino)acetamido)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 5 h / 20 °C / 760.05 Torr

2: dmap; benzotriazol-1-ol; dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 20 h / 20 °C / Inert atmosphere

With dmap; palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2011.12.030