2-chloro-6-phenyl-9-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)purine

Base Information

• Chemical Name: 2-chloro-6-phenyl-9-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)purine
• CAS No.: 442516-98-5
• Molecular Formula: C₃₇H₂₇ClN₄O₇
• Molecular Weight: 675.097
• Mol file: 442516-98-5.mol

Synonyms:2-chloro-6-phenyl-9-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)purine

Chemical Property of 2-chloro-6-phenyl-9-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)purine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-chloro-6-phenyl-9-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)purine

There total 3 articles about 2-chloro-6-phenyl-9-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(2R,3R,4R,5R)-2-((benzoyloxy)methyl)-5-(2,6-dichloro-9H-purin-9-yl)tetrahydrofuran-3,4-diyl dibenzoate (15373-23-6,339091-08-6) + phenylboronic acid (98-80-6) → 2-chloro-6-phenyl-9-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)purine (442516-98-5)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In toluene; at 100 ℃; for 8h;

DOI:10.1135/cccc20020325

Reference yield:

2,6 dichloropurine (5451-40-1) → 2-chloro-6-phenyl-9-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)purine (442516-98-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 52 percent / SnCl₄ / acetonitrile / 6 h / 20 °C

2: 80 percent / [Pd(PPh₃)4]; K₂CO₃ / toluene / 8 h / 100 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tin(IV) chloride; potassium carbonate; In toluene; acetonitrile; 2: Suzuki-Miyaura cross-coupling;

DOI:10.1135/cccc20020325

Reference yield:

1-O-acetyl-2,3,5-tri-O-benzoyl-D-ribofuranose (14215-97-5) → 2-chloro-6-phenyl-9-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)purine (442516-98-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 52 percent / SnCl₄ / acetonitrile / 6 h / 20 °C

2: 80 percent / [Pd(PPh₃)4]; K₂CO₃ / toluene / 8 h / 100 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tin(IV) chloride; potassium carbonate; In toluene; acetonitrile; 2: Suzuki-Miyaura cross-coupling;

DOI:10.1135/cccc20020325

upstream raw materials:

(2R,3R,4R,5R)-2-((benzoyloxy)methyl)-5-(2,6-dichloro-9H-purin-9-yl)tetrahydrofuran-3,4-diyl dibenzoate

phenylboronic acid

2,6 dichloropurine

1-O-acetyl-2,3,5-tri-O-benzoyl-D-ribofuranose