4-(2-Azido-phenyl)-6-(8-benzyloxy-7-bromo-quinolin-2-yl)-3-methyl-pyridine-2-carbaldehyde

Base Information

Chemical Name:4-(2-Azido-phenyl)-6-(8-benzyloxy-7-bromo-quinolin-2-yl)-3-methyl-pyridine-2-carbaldehyde
CAS No.:154406-10-7
Molecular Formula:C₂₉H₂₀BrN₅O₂
Molecular Weight:550.414
Hs Code.:

Synonyms:4-(2-Azido-phenyl)-6-(8-benzyloxy-7-bromo-quinolin-2-yl)-3-methyl-pyridine-2-carbaldehyde

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Chemical Property of 4-(2-Azido-phenyl)-6-(8-benzyloxy-7-bromo-quinolin-2-yl)-3-methyl-pyridine-2-carbaldehyde

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Technology Process of 4-(2-Azido-phenyl)-6-(8-benzyloxy-7-bromo-quinolin-2-yl)-3-methyl-pyridine-2-carbaldehyde

There total 6 articles about 4-(2-Azido-phenyl)-6-(8-benzyloxy-7-bromo-quinolin-2-yl)-3-methyl-pyridine-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 154406-09-4
2-[4-(2-Azido-phenyl)-5,6-dimethyl-pyridin-2-yl]-8-benzyloxy-7-bromo-quinoline

: 154406-10-7
4-(2-Azido-phenyl)-6-(8-benzyloxy-7-bromo-quinolin-2-yl)-3-methyl-pyridine-2-carbaldehyde

Guidance literature:: With 1,4-dioxane; selenium(IV) oxide; In acetic acid; at 100 ℃;
DOI:10.1039/c39930001463

Reference yield:

: 16714-25-3
2-azidobenzaldehyde

: 154406-10-7
4-(2-Azido-phenyl)-6-(8-benzyloxy-7-bromo-quinolin-2-yl)-3-methyl-pyridine-2-carbaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / 10percent aq. NaOH / ethanol / 25 °C

2: 98 percent / Yb(fod)3 Hfod=1,1,1,2,2,3,3-heptafluoro-7,7-dimethyloctane-4,6-dione, 2-ethoxybut-1-ene / CH₂Cl₂ / Heating

3: 89 percent / HONH₂*HCl / acetonitrile / Heating

4: 87 percent / SeO₂, dioxane / acetic acid / 100 °C

With 1,4-dioxane; sodium hydroxide; selenium(IV) oxide; 2-ethoxy-but-1-ene; Yb(fod)3 Hfod=1,1,1,2,2,3,3-heptafluoro-7,7-dimethyloctane-4,6-dione; hydroxylamine hydrochloride; In ethanol; dichloromethane; acetic acid; acetonitrile;
DOI:10.1039/c39930001463

Reference yield:

: 99573-19-0
3-(benzyloxy)-4-bromo-2-nitrobenzaldehyde

: 154406-10-7
4-(2-Azido-phenyl)-6-(8-benzyloxy-7-bromo-quinolin-2-yl)-3-methyl-pyridine-2-carbaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1: 2.) Na₂S₂O₄, 3.) acid

2: 98 percent / 10percent aq. NaOH / ethanol / 25 °C

3: 98 percent / Yb(fod)3 Hfod=1,1,1,2,2,3,3-heptafluoro-7,7-dimethyloctane-4,6-dione, 2-ethoxybut-1-ene / CH₂Cl₂ / Heating

4: 89 percent / HONH₂*HCl / acetonitrile / Heating

5: 87 percent / SeO₂, dioxane / acetic acid / 100 °C

With 1,4-dioxane; sodium hydroxide; selenium(IV) oxide; sodium dithionite; 2-ethoxy-but-1-ene; Yb(fod)3 Hfod=1,1,1,2,2,3,3-heptafluoro-7,7-dimethyloctane-4,6-dione; hydroxylamine hydrochloride; In ethanol; dichloromethane; acetic acid; acetonitrile;
DOI:10.1039/c39930001463