Technology Process of 3-benzyloxy-4,5-dimethoxyphenylacetonitrile
There total 15 articles about 3-benzyloxy-4,5-dimethoxyphenylacetonitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multistep reaction;
(i) SOCl2, (ii) /BRN= 3587243/, NaI;
DOI:10.1039/j39680000447
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 89 percent / sodium hydroxide; Adogen 464(R) / CH2Cl2 / 15 h / 20 °C
2.1: sodium borohydride / tetrahydrofuran; methanol / 2 h
3.1: imidazole / dimethylformamide / 12 h / 20 °C
4.1: n-butyllithium / 1 h / -78 °C
4.2: trimethyl borate / 12 h / -78 - 20 °C
4.3: 78 percent / hydrogen peroxide / 12 h / 20 °C
5.1: 75 percent / potassium carbonate / acetone / 12 h / Heating
6.1: 100 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 2 h / 0 °C
7.1: SOCl2 / benzene / 12 h / 20 °C
7.2: dimethylsulfoxide; benzene / 20 °C
With
1H-imidazole; sodium hydroxide; sodium tetrahydroborate; n-butyllithium; thionyl chloride; Adogen 464(R); tetrabutyl ammonium fluoride; potassium carbonate;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetone; benzene;
DOI:10.1021/ol0261635
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium borohydride / tetrahydrofuran; methanol / 2 h
2.1: imidazole / dimethylformamide / 12 h / 20 °C
3.1: n-butyllithium / 1 h / -78 °C
3.2: trimethyl borate / 12 h / -78 - 20 °C
3.3: 78 percent / hydrogen peroxide / 12 h / 20 °C
4.1: 75 percent / potassium carbonate / acetone / 12 h / Heating
5.1: 100 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 2 h / 0 °C
6.1: SOCl2 / benzene / 12 h / 20 °C
6.2: dimethylsulfoxide; benzene / 20 °C
With
1H-imidazole; sodium tetrahydroborate; n-butyllithium; thionyl chloride; tetrabutyl ammonium fluoride; potassium carbonate;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetone; benzene;
DOI:10.1021/ol0261635
