(E)-4-(4-(4-aminobenzylidene)-3,4-dihydro-2H-pyrrol-5-yl)aniline

Base Information

• Chemical Name: (E)-4-(4-(4-aminobenzylidene)-3,4-dihydro-2H-pyrrol-5-yl)aniline
• CAS No.: 1372791-24-6
• Molecular Formula: C₁₇H₁₇N₃
• Molecular Weight: 263.342
• Mol file: 1372791-24-6.mol

Synonyms:(E)-4-(4-(4-aminobenzylidene)-3,4-dihydro-2H-pyrrol-5-yl)aniline

Chemical Property of (E)-4-(4-(4-aminobenzylidene)-3,4-dihydro-2H-pyrrol-5-yl)aniline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-4-(4-(4-aminobenzylidene)-3,4-dihydro-2H-pyrrol-5-yl)aniline

There total 7 articles about (E)-4-(4-(4-aminobenzylidene)-3,4-dihydro-2H-pyrrol-5-yl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

C27H33N3O4 (1372791-20-2) → (E)-4-(4-(4-aminobenzylidene)-3,4-dihydro-2H-pyrrol-5-yl)aniline (1372791-24-6)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1021/ja301868p

Reference yield:

tert-butyl N-[4-(2-bromoacetyl)phenyl]carbamate (885269-70-5) → (E)-4-(4-(4-aminobenzylidene)-3,4-dihydro-2H-pyrrol-5-yl)aniline (1372791-24-6)

Guidance literature:

Multi-step reaction with 5 steps

1: 3 h / 160 °C

2: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / dichloromethane / 36 h / Reflux

3: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / tetrahydrofuran / 504 h / 20 °C

4: triphenylphosphine / diethyl ether / 24 h / 20 °C / Inert atmosphere

5: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

With tetra(n-butyl)ammonium hydrogensulfate; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.1021/ja301868p

Reference yield:

C27H33N5O5 → (E)-4-(4-(4-aminobenzylidene)-3,4-dihydro-2H-pyrrol-5-yl)aniline (1372791-24-6)

Guidance literature:

Multi-step reaction with 2 steps

1: triphenylphosphine / diethyl ether / 24 h / 20 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

With triphenylphosphine; trifluoroacetic acid; In diethyl ether; dichloromethane;

DOI:10.1021/ja301868p

upstream raw materials:

tert-butyl N-[4-(2-bromoacetyl)phenyl]carbamate

C₁₉H₂₉N₄O₆P

C₂₇H₃₃N₃O₄

p-aminobenzophenone

Downstream raw materials:

(E)-2-chloro-N-(4-(4-(4-(2-chloroacetamido)benzylidene)-3,4-dihydro-2H-pyrrol-5-yl)phenyl)acetamide