5-{(3S)-3-[(6-{[tert-butyl(dimethyl)silyl]oxy}-2-naphthyl)oxy]pyrrolidin-1-yl}-5-methyl-2,2-diphenylhexanamide

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Chemical Name:5-{(3S)-3-[(6-{[tert-butyl(dimethyl)silyl]oxy}-2-naphthyl)oxy]pyrrolidin-1-yl}-5-methyl-2,2-diphenylhexanamide
CAS No.:931409-83-5
Molecular Formula:C₃₉H₅₀N₂O₃Si
Molecular Weight:622.923
Hs Code.:

Synonyms:5-{(3S)-3-[(6-{[tert-butyl(dimethyl)silyl]oxy}-2-naphthyl)oxy]pyrrolidin-1-yl}-5-methyl-2,2-diphenylhexanamide

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Chemical Property of 5-{(3S)-3-[(6-{[tert-butyl(dimethyl)silyl]oxy}-2-naphthyl)oxy]pyrrolidin-1-yl}-5-methyl-2,2-diphenylhexanamide

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Technology Process of 5-{(3S)-3-[(6-{[tert-butyl(dimethyl)silyl]oxy}-2-naphthyl)oxy]pyrrolidin-1-yl}-5-methyl-2,2-diphenylhexanamide

There total 1 articles about 5-{(3S)-3-[(6-{[tert-butyl(dimethyl)silyl]oxy}-2-naphthyl)oxy]pyrrolidin-1-yl}-5-methyl-2,2-diphenylhexanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 161006-22-0
6-(tert-butyl-dimethyl-silyloxy)-naphthalen-2-ol

: 931409-81-3
5-[(R)-3-hydroxypyrrolidin-1-yl]-5-methyl-2,2-diphenylhexanamide

: 931409-83-5
5-{(3S)-3-[(6-{[tert-butyl(dimethyl)silyl]oxy}-2-naphthyl)oxy]pyrrolidin-1-yl}-5-methyl-2,2-diphenylhexanamide

Guidance literature:: 6-(tert-butyl-dimethyl-silyloxy)-naphthalen-2-ol; 5-[(R)-3-hydroxypyrrolidin-1-yl]-5-methyl-2,2-diphenylhexanamide; With diamide; triphenylphosphine; In tetrahydrofuran; at 0 - 60 ℃; for 36h;

With ammonia; In methanol;

Reference yield: 35.0%

: 931409-83-5
5-{(3S)-3-[(6-{[tert-butyl(dimethyl)silyl]oxy}-2-naphthyl)oxy]pyrrolidin-1-yl}-5-methyl-2,2-diphenylhexanamide

: 5-{(3S)-3-[(6-hydroxy-2-naphthyl)oxy]pyrrolidin-1-yl}-5-methyl-2,2-diphenylhexanamide

Guidance literature:: 5-{(3S)-3-[(6-{[tert-butyl(dimethyl)silyl]oxy}-2-naphthyl)oxy]pyrrolidin-1-yl}-5-methyl-2,2-diphenylhexanamide; With ammonium fluoride; In methanol; water; at 20 ℃; for 18h;

With ammonia; In methanol; dichloromethane; water;