methyl 2-methyl-3-nitro-4-[2-(tetrahydro-2H-pyran-4-yl)-1H-imidazol-1-yl]benzoate

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Chemical Name:methyl 2-methyl-3-nitro-4-[2-(tetrahydro-2H-pyran-4-yl)-1H-imidazol-1-yl]benzoate
CAS No.:1243165-03-8
Molecular Formula:C₁₇H₁₉N₃O₅
Molecular Weight:345.355
Hs Code.:

Synonyms:methyl 2-methyl-3-nitro-4-[2-(tetrahydro-2H-pyran-4-yl)-1H-imidazol-1-yl]benzoate

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Chemical Property of methyl 2-methyl-3-nitro-4-[2-(tetrahydro-2H-pyran-4-yl)-1H-imidazol-1-yl]benzoate

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Technology Process of methyl 2-methyl-3-nitro-4-[2-(tetrahydro-2H-pyran-4-yl)-1H-imidazol-1-yl]benzoate

There total 2 articles about methyl 2-methyl-3-nitro-4-[2-(tetrahydro-2H-pyran-4-yl)-1H-imidazol-1-yl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1033717-12-2
2-(tetrahydro-2H-pyran-4-yl)-1H-imidazole

: 1079991-69-7
methyl 4-fluoro-2-methyl-3-nitrobenzoate

: 1243165-03-8
methyl 2-methyl-3-nitro-4-[2-(tetrahydro-2H-pyran-4-yl)-1H-imidazol-1-yl]benzoate

Guidance literature:: 2-(tetrahydro-2H-pyran-4-yl)-1H-imidazole; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.666667h; Cooling with ice;

methyl 4-fluoro-2-methyl-3-nitrobenzoate; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; Cooling with ice;

Reference yield:

: 174403-69-1
4-fluoro-2-methyl benzoic acid methyl ester

: 1243165-03-8
methyl 2-methyl-3-nitro-4-[2-(tetrahydro-2H-pyran-4-yl)-1H-imidazol-1-yl]benzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium nitrate; sulfuric acid / 4.17 h / -10 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.67 h / 20 °C / Cooling with ice

2.2: 20 °C / Cooling with ice

With sulfuric acid; sodium hydride; potassium nitrate; In N,N-dimethyl-formamide; mineral oil;