2,5-Difluorotyrosine

Base Information

Chemical Name:2,5-Difluorotyrosine
CAS No.:182756-52-1
Molecular Formula:C₉H₉F₂NO₃
Molecular Weight:217.172
Hs Code.:
DSSTox Substance ID:DTXSID601313519
Nikkaji Number:J923.239G

Synonyms:2,5-difluorotyrosine;2,5-Difluoro-L-tyrosine;SCHEMBL5324673;DTXSID601313519;182756-52-1

Suppliers and Price of 2,5-Difluorotyrosine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of 2,5-Difluorotyrosine

Chemical Property:

XLogP3:-1.6
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:217.05504947
Heavy Atom Count:15
Complexity:239

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=C(C(=CC(=C1F)O)F)CC(C(=O)O)N
Isomeric SMILES:C1=C(C(=CC(=C1F)O)F)C[C@@H](C(=O)O)N

Technology Process of 2,5-Difluorotyrosine

There total 1 articles about 2,5-Difluorotyrosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2713-31-7
2,5-difluorophenol

: 127-17-3
2-oxo-propionic acid

: 182756-52-1
2,5-difluorotyrosine

Guidance literature:: With ammonium hydroxide; tyrosine phenollylase; pyridoxal 5'-phosphate; ammonium acetate; 2-hydroxyethanethiol; In water; Ambient temperature;
DOI:10.1021/ja9808393

Reference yield:

: 182756-52-1
2,5-difluorotyrosine

: 197972-07-9
(S)-4-{(S)-2-[(S)-2-((S)-2-Amino-4-carboxy-butyrylamino)-3-carboxy-propionylamino]-3-carbamoyl-propionylamino}-4-[(S)-1-[(1S,2R)-1-((S)-1-carboxy-ethylcarbamoyl)-2-hydroxy-propylcarbamoyl]-2-(2,5-difluoro-4-hydroxy-phenyl)-ethylcarbamoyl]-butyric acid

Guidance literature:: Multi-step reaction with 2 steps

1: 10percent aq. Na₂CO₃ / dioxane / Ambient temperature

With sodium carbonate; In 1,4-dioxane;
DOI:10.1021/ja9808393

Reference yield:

: 182756-52-1
2,5-difluorotyrosine

: C₃₄H₄₇F₂N₈O₂₀P

Guidance literature:: Multi-step reaction with 3 steps

1: 10percent aq. Na₂CO₃ / dioxane / Ambient temperature

3: ATP, Csk, pyruvate kinase-lactate dehydrogenase, phosphenolpyruvate, DTT, MnCl₂, Tris-HCl pH 7.4 / H₂O / 48 h / 30 °C

With DL-dithiothreitol; phosphenolpyruvate; pyruvate kinase-lactate dehydrogenase; tris hydrochloride; sodium carbonate; ATP; manganese(ll) chloride; In 1,4-dioxane; water;
DOI:10.1021/ja9808393