methyl 2-((6-((2,6-diisopropylphenyl)amino)-6-oxohexyl)thio)benzo[d]oxazole-7-carboxylate

Base Information

• Chemical Name: methyl 2-((6-((2,6-diisopropylphenyl)amino)-6-oxohexyl)thio)benzo[d]oxazole-7-carboxylate
• CAS No.: 213685-02-0
• Molecular Formula: C₂₇H₃₄N₂O₄S
• Molecular Weight: 482.644
• Mol file: 213685-02-0.mol

Synonyms:methyl 2-((6-((2,6-diisopropylphenyl)amino)-6-oxohexyl)thio)benzo[d]oxazole-7-carboxylate

Chemical Property of methyl 2-((6-((2,6-diisopropylphenyl)amino)-6-oxohexyl)thio)benzo[d]oxazole-7-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-((6-((2,6-diisopropylphenyl)amino)-6-oxohexyl)thio)benzo[d]oxazole-7-carboxylate

There total 4 articles about methyl 2-((6-((2,6-diisopropylphenyl)amino)-6-oxohexyl)thio)benzo[d]oxazole-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-sulfanyl-7-(methoxy)carbonyl-1,3-benzoxazole (213685-64-4) + 6-bromo-N-(2,6-diisopropylphenyl)hexanamide (199592-72-8) → methyl 2-((6-((2,6-diisopropylphenyl)amino)-6-oxohexyl)thio)benzo[d]oxazole-7-carboxylate (213685-02-0)

Guidance literature:

With 18-crown-6 ether; potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 2h;

DOI:10.1016/j.bmc.2018.06.024

Reference yield:

3-aminosalicylic acid (570-23-0) → methyl 2-((6-((2,6-diisopropylphenyl)amino)-6-oxohexyl)thio)benzo[d]oxazole-7-carboxylate (213685-02-0)

Guidance literature:

Multi-step reaction with 3 steps

1: ethanol / 2.5 h / Reflux

2: toluene-4-sulfonic acid / 72 h / Reflux

3: potassium carbonate; 18-crown-6 ether / N,N-dimethyl-formamide / 2 h / 80 °C

With 18-crown-6 ether; potassium carbonate; toluene-4-sulfonic acid; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2018.06.024

Reference yield:

2-mercaptobenzo[d]oxazole-7-carboxylic acid → methyl 2-((6-((2,6-diisopropylphenyl)amino)-6-oxohexyl)thio)benzo[d]oxazole-7-carboxylate (213685-02-0)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / 72 h / Reflux

2: potassium carbonate; 18-crown-6 ether / N,N-dimethyl-formamide / 2 h / 80 °C

With 18-crown-6 ether; potassium carbonate; toluene-4-sulfonic acid; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2018.06.024

upstream raw materials:

3-aminosalicylic acid

2-sulfanyl-7-(methoxy)carbonyl-1,3-benzoxazole

6-bromo-N-(2,6-diisopropylphenyl)hexanamide

6-bromohexanoic acid

Downstream raw materials:

2-((6-((2,6-diisopropylphenyl)amino)-6-oxohexyl)thio)benzo[d]oxazole-7-carboxylic acid

N-(2,6-diisopropylphenyl)-6-((7-(hydroxymethyl)benzo[d]oxazol-2-yl)thio)hexanamide

N-(2,6-diisopropylphenyl)-6-((7-((N,N-dimethylamino)methyl)benzo[d]oxazol-2-yl)thio)hexanamide

t-butyl (2-((6-((N-2,6-diisopropylphenyl)amino)-6-oxohexyl)thio)benzo[d]oxazol-7-yl)carbamate