4-chloro-6-((2-(4-((3,3-difluoropyrrolidin-1-yl)carbonyl)-2-methylphenyl)pyrrolidin-1-yl)carbonyl)benzene-1,3-diol

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Chemical Name:4-chloro-6-((2-(4-((3,3-difluoropyrrolidin-1-yl)carbonyl)-2-methylphenyl)pyrrolidin-1-yl)carbonyl)benzene-1,3-diol
CAS No.:1023885-08-6
Molecular Formula:C₂₃H₂₃ClF₂N₂O₄
Molecular Weight:464.896
Hs Code.:

Synonyms:4-chloro-6-((2-(4-((3,3-difluoropyrrolidin-1-yl)carbonyl)-2-methylphenyl)pyrrolidin-1-yl)carbonyl)benzene-1,3-diol

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Chemical Property of 4-chloro-6-((2-(4-((3,3-difluoropyrrolidin-1-yl)carbonyl)-2-methylphenyl)pyrrolidin-1-yl)carbonyl)benzene-1,3-diol

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Technology Process of 4-chloro-6-((2-(4-((3,3-difluoropyrrolidin-1-yl)carbonyl)-2-methylphenyl)pyrrolidin-1-yl)carbonyl)benzene-1,3-diol

There total 2 articles about 4-chloro-6-((2-(4-((3,3-difluoropyrrolidin-1-yl)carbonyl)-2-methylphenyl)pyrrolidin-1-yl)carbonyl)benzene-1,3-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1023888-15-4
C₂₇H₃₁ClF₂N₂O₆

: 1023885-08-6
4-chloro-6-((2-(4-((3,3-difluoropyrrolidin-1-yl)carbonyl)-2-methylphenyl)pyrrolidin-1-yl)carbonyl)benzene-1,3-diol

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 23 ℃; for 12h;
DOI:10.1016/j.bmcl.2008.09.081

Reference yield: 34.0%

: 1023888-14-3
3,3-difluoro-1-(3-methyl-4-pyrrolidin-2-ylbenzoyl)pyrrolidine

: 67828-44-8
5-chloro-2,4-dihydroxy-benzoic acid

: 1023885-08-6
4-chloro-6-((2-(4-((3,3-difluoropyrrolidin-1-yl)carbonyl)-2-methylphenyl)pyrrolidin-1-yl)carbonyl)benzene-1,3-diol

Guidance literature:: 3,3-difluoro-1-(3-methyl-4-pyrrolidin-2-ylbenzoyl)pyrrolidine; 5-chloro-2,4-dihydroxy-benzoic acid; With triethylamine; HATU; In N,N-dimethyl-formamide; at 60 ℃; for 16h;

With hydrogenchloride; In 1,4-dioxane; for 3h;