Pilosinine

Base Information

Chemical Name:Pilosinine
CAS No.:38993-86-1
Molecular Formula:C₉H₁₂N₂O₂
Molecular Weight:180.206
Hs Code.:
ChEMBL ID:CHEMBL313046
DSSTox Substance ID:DTXSID301167533
Nikkaji Number:J442.728I
Wikidata:Q110183808

Synonyms:(4R)-4-((3-methylimidazol-4-yl)methyl)oxolan-2-one;pilosinine

Suppliers and Price of Pilosinine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of Pilosinine

Chemical Property:

Vapor Pressure:0mmHg at 25°C
XLogP3:0.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:180.089877630
Heavy Atom Count:13
Complexity:208

Purity/Quality:: 99% ,98%,Electron Grade , ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CN1C=NC=C1CC2CC(=O)OC2
Isomeric SMILES:CN1C=NC=C1C[C@@H]2CC(=O)OC2

Technology Process of Pilosinine

There total 12 articles about Pilosinine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 38622-91-2,36635-61-7
[(p-methylphenyl)sulfonylmethyl]isonitrile

: C₇H₁₁NO₂

: 38993-86-1
(+)-pilosinine

Guidance literature:: With triethylamine; In dichloromethane; at 25 ℃; for 168h; Inert atmosphere;
DOI:10.1016/j.tetlet.2020.151945

Reference yield:

: 39021-62-0
1-methylimidazole-5-carbaldehyde

: 38993-86-1
(+)-pilosinine

Guidance literature:: Multi-step reaction with 5 steps

1: 1) NaH / THF, 0 deg C

2: 95 percent / H₂ / 10percent Pd-C / methanol

3: 1) NaN(SiMe₃)2 / 1) THF, -78 deg C, 3 h, 2) -60 deg C, 3 h

4: Zn(BH₄)2 / diethyl ether / 120 h / Ambient temperature

5: 95percent aq. CF₃COOH / 0 °C

With zinc(II) tetrahydroborate; hydrogen; sodium hexamethyldisilazane; sodium hydride; trifluoroacetic acid; palladium on activated charcoal; In methanol; diethyl ether;
DOI:10.1016/S0040-4039(00)92211-1

Reference yield:

: 142143-25-7
(S)-4-Benzyl-3-[(E)-3-(3-methyl-3H-imidazol-4-yl)-acryloyl]-oxazolidin-2-one

: 38993-86-1
(+)-pilosinine

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / H₂ / 10percent Pd-C / methanol

2: 1) NaN(SiMe₃)2 / 1) THF, -78 deg C, 3 h, 2) -60 deg C, 3 h

3: Zn(BH₄)2 / diethyl ether / 120 h / Ambient temperature

4: 95percent aq. CF₃COOH / 0 °C

With zinc(II) tetrahydroborate; hydrogen; sodium hexamethyldisilazane; trifluoroacetic acid; palladium on activated charcoal; In methanol; diethyl ether;
DOI:10.1016/S0040-4039(00)92211-1