methyl (2S)-4-{[4-(1-benzofuran-2-yl)benzoyl]amino}-2-[(benzyloxy)methoxy]butanoate

Base Information

Chemical Name:methyl (2S)-4-{[4-(1-benzofuran-2-yl)benzoyl]amino}-2-[(benzyloxy)methoxy]butanoate
CAS No.:223466-52-2
Molecular Formula:C₂₈H₂₇NO₆
Molecular Weight:473.525
Hs Code.:

Synonyms:methyl (2S)-4-{[4-(1-benzofuran-2-yl)benzoyl]amino}-2-[(benzyloxy)methoxy]butanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (2S)-4-{[4-(1-benzofuran-2-yl)benzoyl]amino}-2-[(benzyloxy)methoxy]butanoate

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Technology Process of methyl (2S)-4-{[4-(1-benzofuran-2-yl)benzoyl]amino}-2-[(benzyloxy)methoxy]butanoate

There total 8 articles about methyl (2S)-4-{[4-(1-benzofuran-2-yl)benzoyl]amino}-2-[(benzyloxy)methoxy]butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 223466-49-7
methyl (2S)-4-{[4-(1-benzofuran-2-yl)benzoyl]amino}-2-hydroxybutanoate

: 3587-60-8
Benzyloxymethyl chloride

: 223466-52-2
methyl (2S)-4-{[4-(1-benzofuran-2-yl)benzoyl]amino}-2-[(benzyloxy)methoxy]butanoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 50 ℃; for 0.5h;
DOI:10.1016/j.bmc.2006.03.032

Reference yield:

: 905291-44-3
methyl (2S)-4-azido-2-hydroxybutanoate

: 223466-52-2
methyl (2S)-4-{[4-(1-benzofuran-2-yl)benzoyl]amino}-2-[(benzyloxy)methoxy]butanoate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen; HCl / palladium on carbon / methanol / 2 h / 20 °C / atmospheric pressure

2: 1.61 g / triethylamine / CH₂Cl₂ / 2 h / 20 °C

3: 66 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 0.5 h / 50 °C

With hydrogenchloride; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1016/j.bmc.2006.03.032

Reference yield:

: 98437-24-2
benzofuran-2-boronic acid

: 223466-52-2
methyl (2S)-4-{[4-(1-benzofuran-2-yl)benzoyl]amino}-2-[(benzyloxy)methoxy]butanoate

Guidance literature:: Multi-step reaction with 5 steps

1: 75 percent / triethylamine / dichlorobis(triphenylphosphine)palladium(II) / dimethylformamide / 6 h / 80 °C

2: 69 percent / sodium hydroxide / dioxane; H₂O / 9 h / 20 °C

3: 88 percent / SOCl₂ / 3 h / Heating

4: 1.61 g / triethylamine / CH₂Cl₂ / 2 h / 20 °C

5: 66 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 0.5 h / 50 °C

With sodium hydroxide; thionyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; 1: Suzuki coupling;
DOI:10.1016/j.bmc.2006.03.032