tert-butyl 2-(5-bromo-2-nitrophenyl)ethanoate

Base Information

• Chemical Name: tert-butyl 2-(5-bromo-2-nitrophenyl)ethanoate
• CAS No.: 878672-60-7
• Molecular Formula: C₁₂H₁₄BrNO₄
• Molecular Weight: 316.151
• Mol file: 878672-60-7.mol

Synonyms:tert-butyl 2-(5-bromo-2-nitrophenyl)ethanoate

Chemical Property of tert-butyl 2-(5-bromo-2-nitrophenyl)ethanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 2-(5-bromo-2-nitrophenyl)ethanoate

There total 1 articles about tert-butyl 2-(5-bromo-2-nitrophenyl)ethanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

tert-Butyl chloroacetate (107-59-5) + para-nitrophenyl bromide (586-78-7) → tert-butyl 2-(5-bromo-2-nitrophenyl)ethanoate (878672-60-7)

Guidance literature:

With potassium tert-butylate; In N,N-dimethyl-formamide; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1002/anie.201106559

Reference yield: 100.0%

1,3,5-Trioxan (110-88-3) + tert-butyl 2-(5-bromo-2-nitrophenyl)ethanoate (878672-60-7) → tert-butyl 2-(5-bromo-2-nitrophenyl)propenoate (1033265-31-4)

Guidance literature:

With piperidine; acetic acid; In benzene; for 48h; Heating;

DOI:10.1055/s-2008-1032208

Reference yield: 90.0%

tert-butyl 2-(5-bromo-2-nitrophenyl)ethanoate (878672-60-7) → tert-butyl 2-(2-amino-3-methylphenyl)acetate (878673-09-7)

Guidance literature:

With hydrogen; nickel; In ethanol; at 20 ℃; for 2h; under 2585.81 Torr;

upstream raw materials:

tert-Butyl chloroacetate

para-nitrophenyl bromide

Downstream raw materials:

2-(5-bromo-2-nitrophenyl)ethanol

tert-butyl 2-(2-amino-3-methylphenyl)acetate

tert-butyl 2-(5-bromo-2-nitrophenyl)propenoate

2-(5-bromo-2-(phenylthio)phenyl)acetic acid

Refernces

• 1、 Donato, Loic,Mourot, Alexandre,Davenport, Christopher M.,Herbivo, Cyril,Warther, David,Leonard, Jeremie,Bolze, Frederic,Nicoud, Jean-Francois,Kramer, Richard H.,Goeldner, Maurice,Specht, Alexandre. "Water-soluble, donor-acceptor biphenyl derivatives in the 2-(o-nitrophenyl)propyl series: Highly efficient two-photon uncaging of the neurotransmitter γ-aminobutyric acid at λ=800 nm". supporting information; experimental part. p. 1840 - 1843. Retrieved 2012/04/04.
• 2、 Soederberg, Bjoern C. G.,Banini, Serge R.,Turner, Michael R.,Minter, Aaron R.,Arrington, Amanda K.. "Palladium-catalyzed synthesis of 3-indolecarboxylic acid derivatives". . p. 903 - 912. Retrieved 2008/09/21.