7-methyl-3-(4-(trifluoromethyl)phenyl)-4'H-spiro[isoindole-1,1'-naphthalen]-4'-one

Base Information

Chemical Name:7-methyl-3-(4-(trifluoromethyl)phenyl)-4'H-spiro[isoindole-1,1'-naphthalen]-4'-one
CAS No.:1383378-52-6
Molecular Formula:C₂₅H₁₆F₃NO
Molecular Weight:403.403
Hs Code.:

Synonyms:7-methyl-3-(4-(trifluoromethyl)phenyl)-4'H-spiro[isoindole-1,1'-naphthalen]-4'-one

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Chemical Property of 7-methyl-3-(4-(trifluoromethyl)phenyl)-4'H-spiro[isoindole-1,1'-naphthalen]-4'-one

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Technology Process of 7-methyl-3-(4-(trifluoromethyl)phenyl)-4'H-spiro[isoindole-1,1'-naphthalen]-4'-one

There total 5 articles about 7-methyl-3-(4-(trifluoromethyl)phenyl)-4'H-spiro[isoindole-1,1'-naphthalen]-4'-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₅H₁₈F₃N

: 1383378-52-6
7-methyl-3-(4-(trifluoromethyl)phenyl)-4'H-spiro[isoindole-1,1'-naphthalen]-4'-one

Guidance literature:: With 1,10-Phenanthroline; water; copper diacetate; In N,N-dimethyl-formamide; at 20 ℃; for 19h; under 760.051 Torr;
DOI:10.1021/ol301583y

Reference yield:

: 1257630-07-1,1370470-28-2,1374122-56-1
3-methyl-2-(naphthalen-1-yl)benzaldehyde

: 1383378-52-6
7-methyl-3-(4-(trifluoromethyl)phenyl)-4'H-spiro[isoindole-1,1'-naphthalen]-4'-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydroxylamine hydrochloride / dimethyl sulfoxide / 3 h / 100 °C

2.1: diethyl ether / 2 h / 80 °C / Cooling with ice

2.2: 0 °C

3.1: 1,10-Phenanthroline; water; copper diacetate / N,N-dimethyl-formamide / 19 h / 20 °C / 760.05 Torr

With 1,10-Phenanthroline; hydroxylamine hydrochloride; water; copper diacetate; In diethyl ether; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/ol301583y

Reference yield:

: 109179-31-9
2-bromo-3-methyl-benzaldehyde

: 1383378-52-6
7-methyl-3-(4-(trifluoromethyl)phenyl)-4'H-spiro[isoindole-1,1'-naphthalen]-4'-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / Inert atmosphere; Reflux

2.1: hydroxylamine hydrochloride / dimethyl sulfoxide / 3 h / 100 °C

3.1: diethyl ether / 2 h / 80 °C / Cooling with ice

3.2: 0 °C

4.1: 1,10-Phenanthroline; water; copper diacetate / N,N-dimethyl-formamide / 19 h / 20 °C / 760.05 Torr

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,10-Phenanthroline; hydroxylamine hydrochloride; water; copper diacetate; In 1,2-dimethoxyethane; diethyl ether; dimethyl sulfoxide; N,N-dimethyl-formamide; 1.1: Suzuki-Miyaura cross coupling reaction;
DOI:10.1021/ol301583y