D-Lysine,N6-formyl-N6-hydroxy-N2-[[2-(2-hydroxyphenyl)-5-methyl-4-oxazolyl]carbonyl]-,(1S)-1-[2-[[(3S)-hexahydro-1-hydroxy-2-oxo-1H-azepin-3-yl]amino]-1,1-dimethyl-2-oxoethyl]octylester

Base Information

Chemical Name:D-Lysine,N6-formyl-N6-hydroxy-N2-[[2-(2-hydroxyphenyl)-5-methyl-4-oxazolyl]carbonyl]-,(1S)-1-[2-[[(3S)-hexahydro-1-hydroxy-2-oxo-1H-azepin-3-yl]amino]-1,1-dimethyl-2-oxoethyl]octylester
CAS No.:225505-77-1
Molecular Formula:C36H53 N5 O10
Molecular Weight:715.844
Hs Code.:
Mol file:225505-77-1.mol

D-Lysine,N6-formyl-N6-hydroxy-N2-[[2-(2-hydroxyphenyl)-5-methyl-4-oxazolyl]carbonyl]-,(1S)-1-[2-[[(3S)-hexahydro-1-hydroxy-2-oxo-1H-azepin-3-yl]amino]-1,1-dimethyl-2-oxoethyl]octylester

Synonyms:AmamistatinB

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Chemical Property of D-Lysine,N6-formyl-N6-hydroxy-N2-[[2-(2-hydroxyphenyl)-5-methyl-4-oxazolyl]carbonyl]-,(1S)-1-[2-[[(3S)-hexahydro-1-hydroxy-2-oxo-1H-azepin-3-yl]amino]-1,1-dimethyl-2-oxoethyl]octylester

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of D-Lysine,N6-formyl-N6-hydroxy-N2-[[2-(2-hydroxyphenyl)-5-methyl-4-oxazolyl]carbonyl]-,(1S)-1-[2-[[(3S)-hexahydro-1-hydroxy-2-oxo-1H-azepin-3-yl]amino]-1,1-dimethyl-2-oxoethyl]octylester

There total 1 articles about D-Lysine,N6-formyl-N6-hydroxy-N2-[[2-(2-hydroxyphenyl)-5-methyl-4-oxazolyl]carbonyl]-,(1S)-1-[2-[[(3S)-hexahydro-1-hydroxy-2-oxo-1H-azepin-3-yl]amino]-1,1-dimethyl-2-oxoethyl]octylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 1007123-27-4
2,5-dioxopyrrolidin-1-yl 2-(2-hydroxyphenyl)-5-methyloxazole-4-carboxylate

: 1007123-26-3
C₂₅H₄₆N₄O₇

: 225505-77-1
((S)-1-((S)-1-(hydroxy)-2-oxoazepan-3-ylamino)-2,2-dimethyl-1-oxodecan-3-yl) 6-(N-(hydroxy)formamido)-(2R)-2-(2-(2-hydroxyphenyl)-5-methyloxazole-4-carboxamido)hexanoate

Guidance literature:: With sodium hydrogencarbonate; In tetrahydrofuran; water; at 20 ℃;
DOI:10.1021/jo7020532

Reference yield:

: 225505-77-1
((S)-1-((S)-1-(hydroxy)-2-oxoazepan-3-ylamino)-2,2-dimethyl-1-oxodecan-3-yl) 6-(N-(hydroxy)formamido)-(2R)-2-(2-(2-hydroxyphenyl)-5-methyloxazole-4-carboxamido)hexanoate

: (R)-6-Formylamino-2-{[2-(2-hydroxy-phenyl)-5-methyl-oxazole-4-carbonyl]-amino}-hexanoic acid (S)-1-[1-methyl-1-((S)-2-oxo-azepan-3-ylcarbamoyl)-ethyl]-octyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 8h;
DOI:10.1016/S0040-4020(00)00591-3

Reference yield:

: 225505-77-1
((S)-1-((S)-1-(hydroxy)-2-oxoazepan-3-ylamino)-2,2-dimethyl-1-oxodecan-3-yl) 6-(N-(hydroxy)formamido)-(2R)-2-(2-(2-hydroxyphenyl)-5-methyloxazole-4-carboxamido)hexanoate

: (R)-6-Formylamino-2-{[2-(2-hydroxy-phenyl)-5-methyl-oxazole-4-carbonyl]-amino}-hexanoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / Pd/C / methanol / 8 h

2: sodium methoxide / 4 h / 20 °C

With hydrogen; sodium methylate; palladium on activated charcoal; In methanol; 1: Hydrogenolysis / 2: methanolysis;
DOI:10.1016/S0040-4020(00)00591-3