(2R,3S,4R)-1,3,4-tris(benzyloxy)hexane-2,5-diethylsulfonate

Base Information

• Chemical Name: (2R,3S,4R)-1,3,4-tris(benzyloxy)hexane-2,5-diethylsulfonate
• CAS No.: 1421782-03-7
• Molecular Formula: C₃₁H₄₀O₉S₂
• Molecular Weight: 620.785
• Mol file: 1421782-03-7.mol

Synonyms:(2R,3S,4R)-1,3,4-tris(benzyloxy)hexane-2,5-diethylsulfonate

Chemical Property of (2R,3S,4R)-1,3,4-tris(benzyloxy)hexane-2,5-diethylsulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,3S,4R)-1,3,4-tris(benzyloxy)hexane-2,5-diethylsulfonate

There total 1 articles about (2R,3S,4R)-1,3,4-tris(benzyloxy)hexane-2,5-diethylsulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

(3R,4R,5R)-3,4,6-tris(benzyloxy)hexane-1,5-diol (911141-03-2) + Ethanesulfonyl chloride (594-44-5) → (2R,3S,4R)-1,3,4-tris(benzyloxy)hexane-2,5-diethylsulfonate (1421782-03-7)

Guidance literature:

(3R,4R,5R)-3,4,6-tris(benzyloxy)hexane-1,5-diol; With triethylamine; In dichloromethane; at 0 ℃; for 0.0833333h; Molecular sieve;

Ethanesulfonyl chloride; In dichloromethane; at 0 ℃; for 3h;

DOI:10.1016/j.ejmech.2014.03.004

Reference yield: 93.0%

(2R,3S,4R)-1,3,4-tris(benzyloxy)hexane-2,5-diethylsulfonate (1421782-03-7) + isopropylamine (75-31-0) → (2S,3R,4R)-1-isopropyl-3,4-bis(benzyloxy)-2-(benzyloxymethyl)piperidine (1600532-78-2)

Guidance literature:

at 80 - 90 ℃;

DOI:10.1016/j.ejmech.2014.03.004

Reference yield: 92.0%

2-(p-tolyl)ethylamine (3261-62-9) + (2R,3S,4R)-1,3,4-tris(benzyloxy)hexane-2,5-diethylsulfonate (1421782-03-7) → (2S,3R,4R)-1-(4-methylphenethyl)-3,4-bis(benzyloxy)-2-(benzyloxymethyl)piperidine (1600532-71-5)

Guidance literature:

at 80 - 90 ℃;

DOI:10.1016/j.ejmech.2014.03.004

upstream raw materials:

(3R,4R,5R)-3,4,6-tris(benzyloxy)hexane-1,5-diol

Ethanesulfonyl chloride

Downstream raw materials:

(2S,3R,4R)-3,4-bis(benzyloxy)-2-(benzyloxymethyl)-1-(furan-2-ylmethyl)piperidine

(2S,3R,4R)-3,4-bis(benzyloxy)-2-(benzyloxymethyl)-1-phenethylpiperidine

(2S,3R,4R)-1-(4-methoxyphenethyl)-3,4-bis(benzyloxy)-2-(benzyloxymethyl)piperidine

(2S,3R,4R)-1-(4-fluorophenethyl)-3,4-bis(benzyloxy)-2-(benzyloxymethyl)piperidine