5-[4-({15-[6-(3-carboxy-4-fluorophenyl)-3-phenyl-1H-pyrazolo[3,4-b]pyridin-4-yl]-15-oxo-4,7,10-trioxa-14-azapentadec-1-yl}carbamoyl)-3-phenyl-1H-pyrazolo[3,4-b]pyridin-6-yl]-2-fluorobenzoic acid

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Chemical Name:5-[4-({15-[6-(3-carboxy-4-fluorophenyl)-3-phenyl-1H-pyrazolo[3,4-b]pyridin-4-yl]-15-oxo-4,7,10-trioxa-14-azapentadec-1-yl}carbamoyl)-3-phenyl-1H-pyrazolo[3,4-b]pyridin-6-yl]-2-fluorobenzoic acid
CAS No.:1446176-43-7
Molecular Formula:C₅₀H₄₄F₂N₈O₉
Molecular Weight:938.944
Hs Code.:

5-[4-({15-[6-(3-carboxy-4-fluorophenyl)-3-phenyl-1H-pyrazolo[3,4-b]pyridin-4-yl]-15-oxo-4,7,10-trioxa-14-azapentadec-1-yl}carbamoyl)-3-phenyl-1H-pyrazolo[3,4-b]pyridin-6-yl]-2-fluorobenzoic acid

Synonyms:5-[4-({15-[6-(3-carboxy-4-fluorophenyl)-3-phenyl-1H-pyrazolo[3,4-b]pyridin-4-yl]-15-oxo-4,7,10-trioxa-14-azapentadec-1-yl}carbamoyl)-3-phenyl-1H-pyrazolo[3,4-b]pyridin-6-yl]-2-fluorobenzoic acid

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Chemical Property of 5-[4-({15-[6-(3-carboxy-4-fluorophenyl)-3-phenyl-1H-pyrazolo[3,4-b]pyridin-4-yl]-15-oxo-4,7,10-trioxa-14-azapentadec-1-yl}carbamoyl)-3-phenyl-1H-pyrazolo[3,4-b]pyridin-6-yl]-2-fluorobenzoic acid

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Technology Process of 5-[4-({15-[6-(3-carboxy-4-fluorophenyl)-3-phenyl-1H-pyrazolo[3,4-b]pyridin-4-yl]-15-oxo-4,7,10-trioxa-14-azapentadec-1-yl}carbamoyl)-3-phenyl-1H-pyrazolo[3,4-b]pyridin-6-yl]-2-fluorobenzoic acid

There total 11 articles about 5-[4-({15-[6-(3-carboxy-4-fluorophenyl)-3-phenyl-1H-pyrazolo[3,4-b]pyridin-4-yl]-15-oxo-4,7,10-trioxa-14-azapentadec-1-yl}carbamoyl)-3-phenyl-1H-pyrazolo[3,4-b]pyridin-6-yl]-2-fluorobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1446176-60-8
methyl 2-fluoro-5-{4-[(15-{6-[4-fluoro-3-(methoxycarbonyl)phenyl]-3-phenyl-1H-pyrazolo[3,4-b]pyridin-4-yl}-15-oxo-4,7,10-trioxa-14-azapentadec-1-yl)carbamoyl]-3-phenyl-1H-pyrazolo[3,4-b]pyridin-6-yl}benzoate

: 1446176-43-7
5-[4-({15-[6-(3-carboxy-4-fluorophenyl)-3-phenyl-1H-pyrazolo[3,4-b]pyridin-4-yl]-15-oxo-4,7,10-trioxa-14-azapentadec-1-yl}carbamoyl)-3-phenyl-1H-pyrazolo[3,4-b]pyridin-6-yl]-2-fluorobenzoic acid

Guidance literature:: With methanol; sodium hydroxide; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 1446176-52-8
ethyl 1-benzyl-6-chloro-1H-pyrazolo[3,4-b]pyridine-4-carboxylate

: 1446176-43-7
5-[4-({15-[6-(3-carboxy-4-fluorophenyl)-3-phenyl-1H-pyrazolo[3,4-b]pyridin-4-yl]-15-oxo-4,7,10-trioxa-14-azapentadec-1-yl}carbamoyl)-3-phenyl-1H-pyrazolo[3,4-b]pyridin-6-yl]-2-fluorobenzoic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium hydroxide / tetrahydrofuran / 2 h / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C / Inert atmosphere

4.1: sulfuric acid / 1 h / 50 °C

5.1: sodium hydrogencarbonate; N-iodo-succinimide / 1,4-dioxane / 24 h / 20 °C

6.1: toluene-4-sulfonic acid / dichloromethane / 12 h / 20 °C

7.1: sodium 2′-dicyclohexylphosphino-2,6-dimethoxy-1,1′-biphenyl-3-sulfonate hydrate; palladium diacetate / N,N-dimethyl-formamide / 0.33 h / 130 °C / Microwave irradiation; Inert atmosphere

8.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 0.25 h / 20 °C

9.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

9.2: 1 h / 20 °C / Inert atmosphere

10.1: sodium hydroxide; methanol / dichloromethane / 1 h / 20 °C

With hydrogenchloride; methanol; N-iodo-succinimide; sulfuric acid; sodium 2′-dicyclohexylphosphino-2,6-dimethoxy-1,1′-biphenyl-3-sulfonate hydrate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; palladium diacetate; sodium hydrogencarbonate; potassium carbonate; caesium carbonate; toluene-4-sulfonic acid; triethylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 74439-45-5
ethyl 1-benzyl-6-hydroxy-1H-pyrazolo[3,4-b]pyridine-4-carboxylate

: 1446176-43-7
5-[4-({15-[6-(3-carboxy-4-fluorophenyl)-3-phenyl-1H-pyrazolo[3,4-b]pyridin-4-yl]-15-oxo-4,7,10-trioxa-14-azapentadec-1-yl}carbamoyl)-3-phenyl-1H-pyrazolo[3,4-b]pyridin-6-yl]-2-fluorobenzoic acid

Guidance literature:: Multi-step reaction with 11 steps

1.1: trichlorophosphate / N,N-dimethyl-formamide / 24 h / 0 - 80 °C / Inert atmosphere

2.1: sodium hydroxide / tetrahydrofuran / 2 h / 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

4.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C / Inert atmosphere

5.1: sulfuric acid / 1 h / 50 °C

6.1: sodium hydrogencarbonate; N-iodo-succinimide / 1,4-dioxane / 24 h / 20 °C

7.1: toluene-4-sulfonic acid / dichloromethane / 12 h / 20 °C

8.1: sodium 2′-dicyclohexylphosphino-2,6-dimethoxy-1,1′-biphenyl-3-sulfonate hydrate; palladium diacetate / N,N-dimethyl-formamide / 0.33 h / 130 °C / Microwave irradiation; Inert atmosphere

9.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 0.25 h / 20 °C

10.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

10.2: 1 h / 20 °C / Inert atmosphere

11.1: sodium hydroxide; methanol / dichloromethane / 1 h / 20 °C

With hydrogenchloride; methanol; N-iodo-succinimide; sulfuric acid; sodium 2′-dicyclohexylphosphino-2,6-dimethoxy-1,1′-biphenyl-3-sulfonate hydrate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; palladium diacetate; sodium hydrogencarbonate; potassium carbonate; caesium carbonate; toluene-4-sulfonic acid; triethylamine; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;