2a-[4-{4-(2-carbamoylphenyl piperazinyl)}butyl]-2a,3,4,5-tetrahydrobenz[cd]indole-2(1H)-one

Base Information

• Chemical Name: 2a-[4-{4-(2-carbamoylphenyl piperazinyl)}butyl]-2a,3,4,5-tetrahydrobenz[cd]indole-2(1H)-one
• CAS No.: 201608-79-9
• Molecular Formula: C₂₆H₃₂N₄O₂
• Molecular Weight: 432.566
• Mol file: 201608-79-9.mol

Synonyms:2a-[4-{4-(2-carbamoylphenyl piperazinyl)}butyl]-2a,3,4,5-tetrahydrobenz[cd]indole-2(1H)-one

Chemical Property of 2a-[4-{4-(2-carbamoylphenyl piperazinyl)}butyl]-2a,3,4,5-tetrahydrobenz[cd]indole-2(1H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2a-[4-{4-(2-carbamoylphenyl piperazinyl)}butyl]-2a,3,4,5-tetrahydrobenz[cd]indole-2(1H)-one

There total 6 articles about 2a-[4-{4-(2-carbamoylphenyl piperazinyl)}butyl]-2a,3,4,5-tetrahydrobenz[cd]indole-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2a-(4-bromobutyl)-2a,3,4,5-tetrahydrobenz[cd]indole-2(1H)-one (201609-25-8) + 4-(2-aminocarbonylphenyl)piperazine (179480-81-0) → 2a-[4-{4-(2-carbamoylphenyl piperazinyl)}butyl]-2a,3,4,5-tetrahydrobenz[cd]indole-2(1H)-one (201608-79-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 96h;

DOI:10.1021/jm0104264

Reference yield: 98.0%

2a-(3-Formylpropyl)-2a,3,4,5-tetrahydrobenz[cd]indole-2(1H)-one (201609-31-6) + 4-(2-aminocarbonylphenyl)piperazine (179480-81-0) → 2a-[4-{4-(2-carbamoylphenyl piperazinyl)}butyl]-2a,3,4,5-tetrahydrobenz[cd]indole-2(1H)-one (201608-79-9)

Guidance literature:

Reference yield:

(RS)-2a,3,4,5-tetrahydro-1H-benz[cd]indol-2-one (96933-21-0) → 2a-[4-{4-(2-carbamoylphenyl piperazinyl)}butyl]-2a,3,4,5-tetrahydrobenz[cd]indole-2(1H)-one (201608-79-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaH / dimethylformamide / 1 h / 0 °C

1.2: 54 percent / dimethylformamide / 0.5 h / 0 °C

2.1: 98 percent / K₂CO₃ / dimethylformamide / 96 h / 20 °C

With sodium hydride; potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1021/jm0104264

upstream raw materials:

2a-(4-bromobutyl)-2a,3,4,5-tetrahydrobenz[cd]indole-2(1H)-one

4-(2-aminocarbonylphenyl)piperazine

(RS)-2a,3,4,5-tetrahydro-1H-benz[cd]indol-2-one

2a-(3-Formylpropyl)-2a,3,4,5-tetrahydrobenz[cd]indole-2(1H)-one