2-[ethanesulfonyl(4-trifluoromethoxyphenyl)methyl]-5-fluoro-1H-benzimidazole

Base Information

Chemical Name:2-[ethanesulfonyl(4-trifluoromethoxyphenyl)methyl]-5-fluoro-1H-benzimidazole
CAS No.:1351159-15-3
Molecular Formula:C₁₇H₁₄F₄N₂O₃S
Molecular Weight:402.369
Hs Code.:

Synonyms:2-[ethanesulfonyl(4-trifluoromethoxyphenyl)methyl]-5-fluoro-1H-benzimidazole

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Chemical Property of 2-[ethanesulfonyl(4-trifluoromethoxyphenyl)methyl]-5-fluoro-1H-benzimidazole

Chemical Property:

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Technology Process of 2-[ethanesulfonyl(4-trifluoromethoxyphenyl)methyl]-5-fluoro-1H-benzimidazole

There total 4 articles about 2-[ethanesulfonyl(4-trifluoromethoxyphenyl)methyl]-5-fluoro-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1351159-12-0
2-[ethylsulfanyl(4-trifluoromethoxyphenyl)methyl]-5-fluoro-1H-benzimidazole

: 1351159-15-3
2-[ethanesulfonyl(4-trifluoromethoxyphenyl)methyl]-5-fluoro-1H-benzimidazole

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; for 1h; Cooling with ice;

Reference yield:

: 367-31-7
4-fluoro-1,2-phenylenediamine

: 1351159-15-3
2-[ethanesulfonyl(4-trifluoromethoxyphenyl)methyl]-5-fluoro-1H-benzimidazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride / water / 1.5 h / Cooling with ice; Reflux

2.1: benzenesulfonic acid / toluene / 40 h / Reflux

3.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

3.2: 4 h / 20 °C / Cooling with ice

4.1: thionyl chloride; pyridine / tetrahydrofuran / 0.5 h / 20 °C

4.2: 1.5 h / 20 °C

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / Cooling with ice

With pyridine; hydrogenchloride; thionyl chloride; 3-chloro-benzenecarboperoxoic acid; benzenesulfonic acid; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane; water; toluene;

Reference yield:

: 1977-72-6
5-fluoro-1H-benzoimidazole

: 1351159-15-3
2-[ethanesulfonyl(4-trifluoromethoxyphenyl)methyl]-5-fluoro-1H-benzimidazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: benzenesulfonic acid / toluene / 40 h / Reflux

2.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

2.2: 4 h / 20 °C / Cooling with ice

3.1: thionyl chloride; pyridine / tetrahydrofuran / 0.5 h / 20 °C

3.2: 1.5 h / 20 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / Cooling with ice

With pyridine; thionyl chloride; 3-chloro-benzenecarboperoxoic acid; benzenesulfonic acid; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane; toluene;