N-[(1,4-dichloro-7-isoquinolinyl)sulphonyl]-N-(2-methoxybenzyl)glycine t-butyl ester

Base Information

• Chemical Name: N-[(1,4-dichloro-7-isoquinolinyl)sulphonyl]-N-(2-methoxybenzyl)glycine t-butyl ester
• CAS No.: 256477-38-0
• Molecular Formula: C₂₃H₂₄Cl₂N₂O₅S
• Molecular Weight: 511.426
• Mol file: 256477-38-0.mol

Synonyms:N-[(1,4-dichloro-7-isoquinolinyl)sulphonyl]-N-(2-methoxybenzyl)glycine t-butyl ester

Chemical Property of N-[(1,4-dichloro-7-isoquinolinyl)sulphonyl]-N-(2-methoxybenzyl)glycine t-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[(1,4-dichloro-7-isoquinolinyl)sulphonyl]-N-(2-methoxybenzyl)glycine t-butyl ester

There total 4 articles about N-[(1,4-dichloro-7-isoquinolinyl)sulphonyl]-N-(2-methoxybenzyl)glycine t-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,4-dichloro-7-isoquinolinesulphonyl chloride (223671-80-5) + N-(2-methoxybenzyl)glycine t-butyl ester + hexane-EtOAc → N-[(1,4-dichloro-7-isoquinolinyl)sulphonyl]-N-(2-methoxybenzyl)glycine t-butyl ester (256477-38-0)

Guidance literature:

In dichloromethane; triethylamine;

Reference yield:

1-isoquinolone (491-30-5) → N-[(1,4-dichloro-7-isoquinolinyl)sulphonyl]-N-(2-methoxybenzyl)glycine t-butyl ester (256477-38-0)

Guidance literature:

Multi-step reaction with 2 steps

1: N-chloro-succinimide / acetonitrile

2: dichloromethane; triethylamine

With N-chloro-succinimide; In dichloromethane; triethylamine; acetonitrile;

Reference yield:

4-chloro-1-oxo-1,2-dihydro-7-isoquinolinesulfonyl chloride (223671-81-6) → N-[(1,4-dichloro-7-isoquinolinyl)sulphonyl]-N-(2-methoxybenzyl)glycine t-butyl ester (256477-38-0)

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate / diethyl ether; acetonitrile

2: dichloromethane; triethylamine

With trichlorophosphate; In diethyl ether; dichloromethane; triethylamine; acetonitrile;

upstream raw materials:

1,4-dichloro-7-isoquinolinesulphonyl chloride

4-chloro-1-oxo-1,2-dihydro-7-isoquinolinesulfonyl chloride

4-chloro-1-(2H)-isoquinolone

1-isoquinolone