(1R,2R)-1-(p-chlorophenyl)-2-nitropropylcarbamic acid tert-butyl ester

Base Information

Chemical Name:(1R,2R)-1-(p-chlorophenyl)-2-nitropropylcarbamic acid tert-butyl ester
CAS No.:937376-22-2
Molecular Formula:C₁₄H₁₉ClN₂O₄
Molecular Weight:314.769
Hs Code.:

Synonyms:(1R,2R)-1-(p-chlorophenyl)-2-nitropropylcarbamic acid tert-butyl ester

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Chemical Property of (1R,2R)-1-(p-chlorophenyl)-2-nitropropylcarbamic acid tert-butyl ester

Chemical Property:

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Technology Process of (1R,2R)-1-(p-chlorophenyl)-2-nitropropylcarbamic acid tert-butyl ester

There total 5 articles about (1R,2R)-1-(p-chlorophenyl)-2-nitropropylcarbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79-24-3
Nitroethane

: (E)-tert-butyl 4-chlorobenzylidenecarbamate

: (1S,2S)-1-(p-chlorophenyl)-2-nitropropylcarbamic acid tert-butyl ester

: 937376-22-2
(1R,2R)-1-(p-chlorophenyl)-2-nitropropylcarbamic acid tert-butyl ester

Guidance literature:: Nitroethane; With para-tert-butylphenol; samarium(III) isopropoxide; chiral Cu-catalyst; In tetrahydrofuran; at -40 ℃; for 1h;

(E)-tert-butyl 4-chlorobenzylidenecarbamate; In tetrahydrofuran; at -40 ℃; for 48h; Further stages. Title compound not separated from byproducts.;
DOI:10.1021/ja0701560

Reference yield:

: 79-24-3
Nitroethane

: (E)-tert-butyl 4-chlorobenzylidenecarbamate

: (1S,2S)-1-(p-chlorophenyl)-2-nitropropylcarbamic acid tert-butyl ester

: 937376-22-2
(1R,2R)-1-(p-chlorophenyl)-2-nitropropylcarbamic acid tert-butyl ester

: 1187084-34-9
(1S,2R)-1-(4-chlorophenyl)-2-nitropropyl-carbamic acid tert-butyl ester

: (1R,2S)-1-(p-chlorophenyl)-2-(nitropropyl)carbamic acid tert-butyl ester

Guidance literature:: With 4 A molecular sieve; chiral Me₂NC(O)-CH(t-Bu)-NHC(S)NH-[2-(AcHN)cyclohexyl]; N-ethyl-N,N-diisopropylamine; In toluene; at 4 ℃; for 18h; Title compound not separated from byproducts;
DOI:10.1002/anie.200461814

Reference yield:

: 79-24-3
Nitroethane

: 774225-25-1
N-(tert-butoxycarbonyl)-α-(phenylsulfonyl)-4-chlorobenzylamine

: (1S,2S)-1-(p-chlorophenyl)-2-nitropropylcarbamic acid tert-butyl ester

: 937376-22-2
(1R,2R)-1-(p-chlorophenyl)-2-nitropropylcarbamic acid tert-butyl ester

: anti-1-(p-chlorophenyl)-2-(nitropropyl)carbamic acid tert-butyl ester

Guidance literature:: With 1-((1R,2R)-2-(dimethylamino)cyclohexyl)-3-(((1R,4aS,10aR)-7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthren-1-yl)methyl)thiourea; potassium carbonate; In chloroform; water; at 0 ℃; for 48h; optical yield given as %ee; Inert atmosphere;
DOI:10.1002/adsc.200900413