13-cyclohexyl-6-[4-(ethoxycarbonyl)-1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl]-3-methoxy-7H-indolo[2,1-a] [2]benzazepine-10-carboxylic acid 1,1-dimethylethyl ester

Base Information

• Chemical Name: 13-cyclohexyl-6-[4-(ethoxycarbonyl)-1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl]-3-methoxy-7H-indolo[2,1-a] [2]benzazepine-10-carboxylic acid 1,1-dimethylethyl ester
• CAS No.: 1127236-92-3
• Molecular Formula: C₃₇H₄₀F₃N₃O₅
• Molecular Weight: 663.737

Synonyms:13-cyclohexyl-6-[4-(ethoxycarbonyl)-1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl]-3-methoxy-7H-indolo[2,1-a] [2]benzazepine-10-carboxylic acid 1,1-dimethylethyl ester

Chemical Property of 13-cyclohexyl-6-[4-(ethoxycarbonyl)-1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl]-3-methoxy-7H-indolo[2,1-a] [2]benzazepine-10-carboxylic acid 1,1-dimethylethyl ester

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Technology Process of 13-cyclohexyl-6-[4-(ethoxycarbonyl)-1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl]-3-methoxy-7H-indolo[2,1-a] [2]benzazepine-10-carboxylic acid 1,1-dimethylethyl ester

There total 1 articles about 13-cyclohexyl-6-[4-(ethoxycarbonyl)-1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl]-3-methoxy-7H-indolo[2,1-a] [2]benzazepine-10-carboxylic acid 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

tert-butyl 13-cyclohexyl-6-((2E,Z)-3-(dimethylamino)-2-(ethoxycarbonyl)-2-propenoyl)-3-methoxy-7H-indolo[2,1-a][2]benzazepine-10-carboxylate (1127234-89-2) + 2,2,2,trifluoroethylhydrazine (5042-30-8) → 13-cyclohexyl-6-[4-(ethoxycarbonyl)-1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl]-3-methoxy-7H-indolo[2,1-a] [2]benzazepine-10-carboxylic acid 1,1-dimethylethyl ester (1127236-92-3)

Guidance literature:

With triethylamine; In ethanol; at 160 ℃; for 2h; Microwave irradiation;

Reference yield: 100.0%

13-cyclohexyl-6-[4-(ethoxycarbonyl)-1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl]-3-methoxy-7H-indolo[2,1-a] [2]benzazepine-10-carboxylic acid 1,1-dimethylethyl ester (1127236-92-3) → 13-cyclohexyl-6-[4-(ethoxycarbonyl)-1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl]-3-methoxy-7H-indolo[2,1-a][2]benzazepine-10-carboxylic acid (1127236-93-4)

Guidance literature:

With trifluoroacetic acid; In 1,2-dichloro-ethane; at 20 ℃; for 2h;

upstream raw materials:

tert-butyl 13-cyclohexyl-6-((2E,Z)-3-(dimethylamino)-2-(ethoxycarbonyl)-2-propenoyl)-3-methoxy-7H-indolo[2,1-a][2]benzazepine-10-carboxylate

2,2,2,trifluoroethylhydrazine

Downstream raw materials:

13-cyclohexyl-6-[4-(ethoxycarbonyl)-1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl]-3-methoxy-7H-indolo[2,1-a][2]benzazepine-10-carboxylic acid

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