Technology Process of methyl 2-(4-((((4R,4aS,6R,7R,7aR,12bS)-3-(cyclopropylmethyl)-9-hydroxy-7-methoxy-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinolin-6-yl)methoxy)methyl)phenoxy)acetate hydrochloride
There total 7 articles about methyl 2-(4-((((4R,4aS,6R,7R,7aR,12bS)-3-(cyclopropylmethyl)-9-hydroxy-7-methoxy-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinolin-6-yl)methoxy)methyl)phenoxy)acetate hydrochloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
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![methyl 2-(4-((((4R,4aS,6R,7R,7aR,12bS)-3-(cyclopropylmethyl)-9-hydroxy-7-methoxy-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinolin-6-yl)methoxy)methyl)phenoxy)acetate hydrochloride](/Databaselist/images/loading.webp)
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1367596-87-9
methyl 2-(4-((((4R,4aS,6R,7R,7aR,12bS)-3-(cyclopropylmethyl)-9-hydroxy-7-methoxy-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinolin-6-yl)methoxy)methyl)phenoxy)acetate hydrochloride
- Guidance literature:
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C42H49NO8;
With
trifluoroacetic acid;
In
dichloromethane;
at 20 ℃;
for 0.5h;
With
ammonia;
In
dichloromethane; water;
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1367596-87-9
methyl 2-(4-((((4R,4aS,6R,7R,7aR,12bS)-3-(cyclopropylmethyl)-9-hydroxy-7-methoxy-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinolin-6-yl)methoxy)methyl)phenoxy)acetate hydrochloride
- Guidance literature:
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Multi-step reaction with 5 steps
1.1: pyridinium p-toluenesulfonate / dichloromethane / 20 °C
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / Inert atmosphere; Cooling with ice
2.2: 6 h / 20 °C
3.1: formic acid; water / methanol / 3 h / 20 °C
4.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C
5.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C
With
formic acid; water; sodium hydride; caesium carbonate; trifluoroacetic acid;
pyridinium p-toluenesulfonate;
In
methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;
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-
1367596-87-9
methyl 2-(4-((((4R,4aS,6R,7R,7aR,12bS)-3-(cyclopropylmethyl)-9-hydroxy-7-methoxy-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinolin-6-yl)methoxy)methyl)phenoxy)acetate hydrochloride
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate / acetonitrile / 20 °C
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / Inert atmosphere; Cooling with ice
2.2: 6 h / 20 °C
3.1: formic acid; water / methanol / 3 h / 20 °C
4.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C
5.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C
With
formic acid; water; sodium hydride; potassium carbonate; caesium carbonate; trifluoroacetic acid;
In
methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile; mineral oil;
