(R)-tert-butyl 3-(3-(2,3-dihydrobenzofuran-5-yl)-1-trityl-1H-indazole-5-carboxamido)piperidine-1-carboxylate

Base Information

Chemical Name:(R)-tert-butyl 3-(3-(2,3-dihydrobenzofuran-5-yl)-1-trityl-1H-indazole-5-carboxamido)piperidine-1-carboxylate
CAS No.:1353254-56-4
Molecular Formula:C₄₅H₄₄N₄O₄
Molecular Weight:704.869
Hs Code.:

Synonyms:(R)-tert-butyl 3-(3-(2,3-dihydrobenzofuran-5-yl)-1-trityl-1H-indazole-5-carboxamido)piperidine-1-carboxylate

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Chemical Property of (R)-tert-butyl 3-(3-(2,3-dihydrobenzofuran-5-yl)-1-trityl-1H-indazole-5-carboxamido)piperidine-1-carboxylate

Chemical Property:

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Technology Process of (R)-tert-butyl 3-(3-(2,3-dihydrobenzofuran-5-yl)-1-trityl-1H-indazole-5-carboxamido)piperidine-1-carboxylate

There total 5 articles about (R)-tert-butyl 3-(3-(2,3-dihydrobenzofuran-5-yl)-1-trityl-1H-indazole-5-carboxamido)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 227305-69-3
2,3-dihydrobenzofuran-5-boronic acid

: 1353254-54-2
(R)-tert-butyl 3-(3-bromo-1-trityl-1H-indazole-5-carboxamido)piperidine-1-carboxylate

: 1353254-56-4
(R)-tert-butyl 3-(3-(2,3-dihydrobenzofuran-5-yl)-1-trityl-1H-indazole-5-carboxamido)piperidine-1-carboxylate

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 80 ℃; Inert atmosphere;

Reference yield:

: ethyl 3-bromo-1H-indazole-5-carboxylate

: 1353254-56-4
(R)-tert-butyl 3-(3-(2,3-dihydrobenzofuran-5-yl)-1-trityl-1H-indazole-5-carboxamido)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran / 0.25 h / 5 - 10 °C

1.2: 20 °C

2.1: lithium hydroxide / tetrahydrofuran / 50 °C

2.2: pH ~ 4

3.1: HATU / N,N-dimethyl-formamide / 0.25 h / 20 °C

3.2: 0.5 h / 20 °C

4.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 80 °C / Inert atmosphere

With sodium hydride; sodium carbonate; HATU; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

: 1353255-12-5
ethyl 1H-indazole-5-carboxylate hydrochloride

: 1353254-56-4
(R)-tert-butyl 3-(3-(2,3-dihydrobenzofuran-5-yl)-1-trityl-1H-indazole-5-carboxamido)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: bromine / ethanol / 18 h / 20 °C

1.2: pH 10 - 11 / Cooling with ice

2.1: sodium hydride / tetrahydrofuran / 0.25 h / 5 - 10 °C

2.2: 20 °C

3.1: lithium hydroxide / tetrahydrofuran / 50 °C

3.2: pH ~ 4

4.1: HATU / N,N-dimethyl-formamide / 0.25 h / 20 °C

4.2: 0.5 h / 20 °C

5.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 80 °C / Inert atmosphere

With bromine; sodium hydride; sodium carbonate; HATU; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl-formamide;