4-((4-((2-fluorophenyl)(hydroxy)methyl)-6-methylpyrimidin-2-yl)amino)benzonitrile

Base Information

Chemical Name:4-((4-((2-fluorophenyl)(hydroxy)methyl)-6-methylpyrimidin-2-yl)amino)benzonitrile
CAS No.:1334320-51-2
Molecular Formula:C₁₉H₁₅FN₄O
Molecular Weight:334.353
Hs Code.:

Synonyms:4-((4-((2-fluorophenyl)(hydroxy)methyl)-6-methylpyrimidin-2-yl)amino)benzonitrile

Suppliers and Price of 4-((4-((2-fluorophenyl)(hydroxy)methyl)-6-methylpyrimidin-2-yl)amino)benzonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-((4-((2-fluorophenyl)(hydroxy)methyl)-6-methylpyrimidin-2-yl)amino)benzonitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-((4-((2-fluorophenyl)(hydroxy)methyl)-6-methylpyrimidin-2-yl)amino)benzonitrile

There total 5 articles about 4-((4-((2-fluorophenyl)(hydroxy)methyl)-6-methylpyrimidin-2-yl)amino)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.5%

: 1334320-31-8
C₁₉H₁₃FN₄O

: 1334320-51-2
4-((4-((2-fluorophenyl)(hydroxy)methyl)-6-methylpyrimidin-2-yl)amino)benzonitrile

Guidance literature:: With potassium borohydride; In methanol; at 0 - 5 ℃; for 2h;
DOI:10.1016/j.bmc.2011.07.023

Reference yield:

: 244768-53-4
C₁₂H₉ClN₄

: 1334320-51-2
4-((4-((2-fluorophenyl)(hydroxy)methyl)-6-methylpyrimidin-2-yl)amino)benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / -20 - 20 °C / Inert atmosphere

2: oxygen; sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 °C

3: potassium borohydride / methanol / 2 h / 0 - 5 °C

With potassium borohydride; oxygen; sodium hydride; In methanol; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmc.2011.07.023

Reference yield:

: 1140520-11-1
C₁₂H₁₀N₄O

: 1334320-51-2
4-((4-((2-fluorophenyl)(hydroxy)methyl)-6-methylpyrimidin-2-yl)amino)benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: trichlorophosphate / 0.5 h / Reflux

2: sodium hydride / N,N-dimethyl-formamide; mineral oil / -20 - 20 °C / Inert atmosphere

3: oxygen; sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 °C

4: potassium borohydride / methanol / 2 h / 0 - 5 °C

With potassium borohydride; oxygen; sodium hydride; trichlorophosphate; In methanol; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmc.2011.07.023