(2R,4S)-4-<oxy>-1-(phenylthio)-6-hepten-2-ol

Base Information

Chemical Name:(2R,4S)-4-<oxy>-1-(phenylthio)-6-hepten-2-ol
CAS No.:171523-99-2
Molecular Formula:C₁₉H₃₂O₂SSi
Molecular Weight:352.613
Hs Code.:

(2R,4S)-4-<<Dimethyl(2-methyl-2-propyl)silyl>oxy>-1-(phenylthio)-6-hepten-2-ol

Synonyms:(2R,4S)-4-<oxy>-1-(phenylthio)-6-hepten-2-ol

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Chemical Property of (2R,4S)-4-<oxy>-1-(phenylthio)-6-hepten-2-ol

Chemical Property:

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Technology Process of (2R,4S)-4-<oxy>-1-(phenylthio)-6-hepten-2-ol

There total 7 articles about (2R,4S)-4-<oxy>-1-(phenylthio)-6-hepten-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 130481-49-1
(4S,6R)-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-6,7-epoxy-1-heptene

: 108-98-5
thiophenol

: 171523-99-2
(2R,4S)-4-<oxy>-1-(phenylthio)-6-hepten-2-ol

Guidance literature:: With sodium hydroxide; In tert-butyl alcohol; at 55 - 60 ℃; for 1h;
DOI:10.1021/jo00129a019

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 171523-99-2
(2R,4S)-4-<oxy>-1-(phenylthio)-6-hepten-2-ol

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / NEt₃ / CH₂Cl₂ / 0.08 h / 0 °C

2: i-Bu₂AlH / toluene; hexane / 0.08 h / 0 °C

3: 100 percent / benzene; H₂O / 0.5 h / Heating

4: i-Bu₂AlH / CH₂Cl₂; hexane / 0.08 h / -23 °C

5: 52 percent / n-t-Bu₄NCl, 50percent aq. NaOH / CHCl₃ / 1.5 h

6: 92 percent / 0.5 N aq. NaOH / 2-methyl-propan-2-ol / 1 h / 55 - 60 °C

With sodium hydroxide; tetrabutyl-ammonium chloride; diisobutylaluminium hydride; triethylamine; In hexane; dichloromethane; chloroform; water; toluene; tert-butyl alcohol; benzene;
DOI:10.1021/jo00129a019

Reference yield:

: 130459-39-1
2-Phenyl-4(S)-(2(S)-hydroxypent-4-enyl)-2-oxazoline

: 171523-99-2
(2R,4S)-4-<oxy>-1-(phenylthio)-6-hepten-2-ol

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / NEt₃ / CH₂Cl₂ / 0.08 h / 0 °C

2: i-Bu₂AlH / toluene; hexane / 0.08 h / 0 °C

3: 100 percent / benzene; H₂O / 0.5 h / Heating

4: i-Bu₂AlH / CH₂Cl₂; hexane / 0.08 h / -23 °C

5: 52 percent / n-t-Bu₄NCl, 50percent aq. NaOH / CHCl₃ / 1.5 h

6: 92 percent / 0.5 N aq. NaOH / 2-methyl-propan-2-ol / 1 h / 55 - 60 °C

With sodium hydroxide; tetrabutyl-ammonium chloride; diisobutylaluminium hydride; triethylamine; In hexane; dichloromethane; chloroform; water; toluene; tert-butyl alcohol; benzene;
DOI:10.1021/jo00129a019