N-<2(S)-<<<(N-carbobenzoxyamino)methyl>methoxyphosphinyl>methyl>-4-methylpentanoyl>glycine methyl ester

Base Information

Chemical Name:N-<2(S)-<<<(N-carbobenzoxyamino)methyl>methoxyphosphinyl>methyl>-4-methylpentanoyl>glycine methyl ester
CAS No.:131066-47-2
Molecular Formula:C₂₀H₃₁N₂O₇P
Molecular Weight:442.449
Hs Code.:

Synonyms:N-<2(S)-<<<(N-carbobenzoxyamino)methyl>methoxyphosphinyl>methyl>-4-methylpentanoyl>glycine methyl ester

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Chemical Property of N-<2(S)-<<<(N-carbobenzoxyamino)methyl>methoxyphosphinyl>methyl>-4-methylpentanoyl>glycine methyl ester

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Technology Process of N-<2(S)-<<<(N-carbobenzoxyamino)methyl>methoxyphosphinyl>methyl>-4-methylpentanoyl>glycine methyl ester

There total 5 articles about N-<2(S)-<<<(N-carbobenzoxyamino)methyl>methoxyphosphinyl>methyl>-4-methylpentanoyl>glycine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3070-69-7
methyl 2-(2-methylpropyl)acrylate

: 131066-47-2
N-<2(S)-<<<(N-carbobenzoxyamino)methyl>methoxyphosphinyl>methyl>-4-methylpentanoyl>glycine methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: bis(trimethylsilyl)acetamide (BSA) / acetonitrile / Ambient temperature

2: acetonitrile; methanol; diethyl ether / 0 °C

3: 27 percent / 0.055 M borate buffer (pH 8.1) / 24 h / subtilisin Carlsberg (protease IV)

4: 1.) isobutyl chloroformate (IBCF), N-methylmorpholine / 1.) CH₃CN, -5 deg C, 3 min, 2.) a) -5 deg C, 2 h, b) RT, 2 h

With 4-methyl-morpholine; borate buffer; bis-(trimethylsilyl)acetamide; isobutyl chloroformate; In methanol; diethyl ether; acetonitrile;
DOI:10.1021/ja00001a043

Reference yield:

: 131066-43-8
N-benzyloxycarbonylaminomethyl-H-phosphinic acid

: 131066-47-2
N-<2(S)-<<<(N-carbobenzoxyamino)methyl>methoxyphosphinyl>methyl>-4-methylpentanoyl>glycine methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: bis(trimethylsilyl)acetamide (BSA) / acetonitrile / Ambient temperature

2: acetonitrile; methanol; diethyl ether / 0 °C

3: 27 percent / 0.055 M borate buffer (pH 8.1) / 24 h / subtilisin Carlsberg (protease IV)

4: 1.) isobutyl chloroformate (IBCF), N-methylmorpholine / 1.) CH₃CN, -5 deg C, 3 min, 2.) a) -5 deg C, 2 h, b) RT, 2 h

With 4-methyl-morpholine; borate buffer; bis-(trimethylsilyl)acetamide; isobutyl chloroformate; In methanol; diethyl ether; acetonitrile;
DOI:10.1021/ja00001a043

Reference yield:

: 2-[(Benzyloxycarbonylamino-methyl)-hydroxy-phosphinoylmethyl]-4-methyl-pentanoic acid methyl ester

: 131066-47-2
N-<2(S)-<<<(N-carbobenzoxyamino)methyl>methoxyphosphinyl>methyl>-4-methylpentanoyl>glycine methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: acetonitrile; methanol; diethyl ether / 0 °C

2: 27 percent / 0.055 M borate buffer (pH 8.1) / 24 h / subtilisin Carlsberg (protease IV)

3: 1.) isobutyl chloroformate (IBCF), N-methylmorpholine / 1.) CH₃CN, -5 deg C, 3 min, 2.) a) -5 deg C, 2 h, b) RT, 2 h

With 4-methyl-morpholine; borate buffer; isobutyl chloroformate; In methanol; diethyl ether; acetonitrile;
DOI:10.1021/ja00001a043