N-CBZ-O-(tetrahydro-2-pyranyl)-L-tyrosylglycine ethyl ester

Base Information

• Chemical Name: N-CBZ-O-(tetrahydro-2-pyranyl)-L-tyrosylglycine ethyl ester
• CAS No.: 122900-02-1
• Molecular Formula: C₂₆H₃₂N₂O₇
• Molecular Weight: 484.549
• Mol file: 122900-02-1.mol

Synonyms:N-CBZ-O-(tetrahydro-2-pyranyl)-L-tyrosylglycine ethyl ester

Chemical Property of N-CBZ-O-(tetrahydro-2-pyranyl)-L-tyrosylglycine ethyl ester

Chemical Property:

Purity/Quality:

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Technology Process of N-CBZ-O-(tetrahydro-2-pyranyl)-L-tyrosylglycine ethyl ester

There total 1 articles about N-CBZ-O-(tetrahydro-2-pyranyl)-L-tyrosylglycine ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

3,4-dihydro-2H-pyran (110-87-2) + N-CBZ-L-tyrosylglycine ethyl ester (41888-91-9) → N-CBZ-O-(tetrahydro-2-pyranyl)-L-tyrosylglycine ethyl ester (122900-02-1)

Guidance literature:

With pyridinium p-toluenesulfonate; In dichloromethane; at 35 ℃; for 72h;

DOI:10.1021/jm00163a044

Reference yield: 93.0%

N-CBZ-O-(tetrahydro-2-pyranyl)-L-tyrosylglycine ethyl ester (122900-02-1) → {(S)-2-Amino-3-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-propionylamino}-acetic acid ethyl ester (122900-03-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 3h; under 760 Torr;

DOI:10.1021/jm00163a044

upstream raw materials:

3,4-dihydro-2H-pyran

N-CBZ-L-tyrosylglycine ethyl ester

Downstream raw materials:

{(S)-2-Amino-3-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-propionylamino}-acetic acid ethyl ester