Boc-Tyr(tBu)-c<-D-Lys-2-Nal-D-Pro-Gly->

Base Information

• Chemical Name: Boc-Tyr(tBu)-c<-D-Lys-2-Nal-D-Pro-Gly->
• CAS No.: 155919-62-3
• Molecular Formula: C₄₄H₅₈N₆O₈
• Molecular Weight: 798.98
• Mol file: 155919-62-3.mol

Synonyms:Boc-Tyr(tBu)-c<-D-Lys-2-Nal-D-Pro-Gly->

Chemical Property of Boc-Tyr(tBu)-c<-D-Lys-2-Nal-D-Pro-Gly->

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Boc-Tyr(tBu)-c<-D-Lys-2-Nal-D-Pro-Gly->

There total 13 articles about Boc-Tyr(tBu)-c<-D-Lys-2-Nal-D-Pro-Gly-> which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

Boc-Tyr(tBu)-D-Lys-2-Nal-D-Pro-Gly-OH (155919-61-2) → Boc-Tyr(tBu)-c<-D-Lys-2-Nal-D-Pro-Gly-> (155919-62-3)

Guidance literature:

With 4-methyl-morpholine; diphenyl phosphoryl azide; In N,N-dimethyl-formamide; at -25 ℃; for 96h;

Reference yield:

N-tert-butoxycarbonyl-3-(2-naphthyl)-L-alanine (56583-58-5,76985-10-9,58438-04-3) → Boc-Tyr(tBu)-c<-D-Lys-2-Nal-D-Pro-Gly-> (155919-62-3)

Guidance literature:

Multi-step reaction with 8 steps

1: N-methylmorpholine / tetrahydrofuran / 0.07 h / -15 °C

2: N-methylmorpholine / tetrahydrofuran / 0.5 h / -15 °C

3: HCl, AcOH / 0.5 h / Ambient temperature

4: N-methylmorpholine / tetrahydrofuran / 0.5 h / -15 °C

5: HCl, AcOH / 0.5 h / Ambient temperature

6: N-methylmorpholine / tetrahydrofuran / 0.5 h / -15 °C

7: 81 percent / H₂ / Pd black / methanol; H₂O / 760 Torr / Ambient temperature

8: 90 percent / N-methylmorpholine, diphenyl phosphorazidate / dimethylformamide / 96 h / -25 °C

With 4-methyl-morpholine; hydrogenchloride; diphenyl phosphoryl azide; hydrogen; acetic acid; palladium; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

Reference yield:

Boc-L-Tyr(But)-OCO2Bui (129778-99-0) → Boc-Tyr(tBu)-c<-D-Lys-2-Nal-D-Pro-Gly-> (155919-62-3)

Guidance literature:

Multi-step reaction with 3 steps

1: N-methylmorpholine / tetrahydrofuran / 0.5 h / -15 °C

2: 81 percent / H₂ / Pd black / methanol; H₂O / 760 Torr / Ambient temperature

3: 90 percent / N-methylmorpholine, diphenyl phosphorazidate / dimethylformamide / 96 h / -25 °C

With 4-methyl-morpholine; diphenyl phosphoryl azide; hydrogen; palladium; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

upstream raw materials:

Boc-Tyr(tBu)-D-Lys-2-Nal-D-Pro-Gly-OH

Boc-L-Tyr(Bu^t)-OCO₂Buⁱ

N-tert-butoxycarbonyl-3-(2-naphthyl)-L-alanine

Boc-Tyr(t-Bu)-OH