Dazopride

Base Information

• Chemical Name: Dazopride
• CAS No.: 70181-03-2
• Molecular Formula: C15H23 Cl N4 O2
• Molecular Weight: 326.82
• UNII: CV07VSP2G8
• DSSTox Substance ID: DTXSID80867875
• Nikkaji Number: J32.844H
• Wikipedia: Dazopride
• Wikidata: Q5243687
• NCI Thesaurus Code: C72732
• ChEMBL ID: CHEMBL2110810
• Mol file: 70181-03-2.mol

Synonyms:4-amino-5-chloro-N-(1,2-diethyl-4-pyrazolidinyl)-2-methoxybenzamide;dazopride;dazopride fumarate

Chemical Property of Dazopride

Chemical Property:

• PKA: 13.31±0.20(Predicted)
• PSA: 70.83000
• Density: 1.27g/cm³
• LogP: 2.44950
• XLogP3: 2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 326.1509537
• Heavy Atom Count: 22
• Complexity: 373

Purity/Quality:

97% ^*data from raw suppliers

DAZOPRIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCN1CC(CN1CC)NC(=O)C2=CC(=C(C=C2OC)N)Cl
• Uses: Stimulant (peristaltic).

Technology Process of Dazopride

There total 3 articles about Dazopride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(acetylamino)-5-chloro-2-methoxybenzoic acid (24201-13-6) + 4-Amino-1,2-diethyl-pyrazolidine (70180-92-6) → 4-Amino-5-chloro-2-methoxy-N-(1.2-diethyl-4-pyrazolidinyl)benzamide (70181-03-2)

Guidance literature:

With thionyl chloride; In chloroform;

Reference yield:

4-acetamido-5-chloro-2-methoxy-benzoic acid thionyl chloride + 4-Amino-1,2-diethyl-pyrazolidine (70180-92-6) → 4-Amino-5-chloro-2-methoxy-N-(1.2-diethyl-4-pyrazolidinyl)benzamide (70181-03-2)

Guidance literature:

Reference yield:

→ 4-Amino-5-chloro-2-methoxy-N-(1.2-diethyl-4-pyrazolidinyl)benzamide (70181-03-2)

Guidance literature:

4-Acetamino-5-chlor-2-methoxy-benzoesaeure, Thionylchlorid, 4-Amino-1,2-diethylpyrazolidin, HCl;

upstream raw materials:

4-Amino-1,2-diethyl-pyrazolidine

4-(acetylamino)-5-chloro-2-methoxybenzoic acid