7-[(2,5-dioxopyrrolidin-1-yl)methyl]-4-(4-fluorophenyl)quinoline-2-carbonitrile

Base Information

Chemical Name:7-[(2,5-dioxopyrrolidin-1-yl)methyl]-4-(4-fluorophenyl)quinoline-2-carbonitrile
CAS No.:1432731-21-9
Molecular Formula:C₂₁H₁₄FN₃O₂
Molecular Weight:359.359
Hs Code.:

Synonyms:7-[(2,5-dioxopyrrolidin-1-yl)methyl]-4-(4-fluorophenyl)quinoline-2-carbonitrile

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Chemical Property of 7-[(2,5-dioxopyrrolidin-1-yl)methyl]-4-(4-fluorophenyl)quinoline-2-carbonitrile

Chemical Property:

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Technology Process of 7-[(2,5-dioxopyrrolidin-1-yl)methyl]-4-(4-fluorophenyl)quinoline-2-carbonitrile

There total 7 articles about 7-[(2,5-dioxopyrrolidin-1-yl)methyl]-4-(4-fluorophenyl)quinoline-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1432731-20-8
4-chloro-7-[(2,5-dioxopyrrolidin-1-yl)methyl]quinoline-2-carbonitrile

: 1765-93-1
4-fluoroboronic acid

: 1432731-21-9
7-[(2,5-dioxopyrrolidin-1-yl)methyl]-4-(4-fluorophenyl)quinoline-2-carbonitrile

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; In 1,4-dioxane; water; at 100 ℃; for 4h;

Reference yield:

: 1044278-42-3
4-chloro-7-methylquinoline-2-carbonitrile

: 1432731-21-9
7-[(2,5-dioxopyrrolidin-1-yl)methyl]-4-(4-fluorophenyl)quinoline-2-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: N-Bromosuccinimide; dibenzoyl peroxide / acetonitrile / 16 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / acetonitrile / 1 h / 100 °C / Microwave irradiation

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / water; 1,4-dioxane / 4 h / 100 °C

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; dibenzoyl peroxide; In 1,4-dioxane; water; acetonitrile; 3: |Suzuki Coupling;

Reference yield:

: 220143-50-0
7-methylquinoline-2-carbonitrile

: 1432731-21-9
7-[(2,5-dioxopyrrolidin-1-yl)methyl]-4-(4-fluorophenyl)quinoline-2-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 - 40 °C

2: trichlorophosphate / chloroform / 70 °C

3: N-Bromosuccinimide; dibenzoyl peroxide / acetonitrile / 16 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / acetonitrile / 1 h / 100 °C / Microwave irradiation

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / water; 1,4-dioxane / 4 h / 100 °C

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; dibenzoyl peroxide; In 1,4-dioxane; dichloromethane; chloroform; water; acetonitrile; 5: |Suzuki Coupling;