tert-butyl ((2R,3S)-2-((tert-butoxycarbonyl)amino)-3-(4-(1,1-difluoroethyl)phenyl)-3-hydroxypropyl)(5-(3-fluoro-6-isoquinolinyl)-1,3-thiazol-2-yl)carbamate

Base Information

• Chemical Name: tert-butyl ((2R,3S)-2-((tert-butoxycarbonyl)amino)-3-(4-(1,1-difluoroethyl)phenyl)-3-hydroxypropyl)(5-(3-fluoro-6-isoquinolinyl)-1,3-thiazol-2-yl)carbamate
• CAS No.: 1236031-12-1
• Molecular Formula: C₃₃H₃₇F₃N₄O₅S
• Molecular Weight: 658.742

Synonyms:tert-butyl ((2R,3S)-2-((tert-butoxycarbonyl)amino)-3-(4-(1,1-difluoroethyl)phenyl)-3-hydroxypropyl)(5-(3-fluoro-6-isoquinolinyl)-1,3-thiazol-2-yl)carbamate

Chemical Property of tert-butyl ((2R,3S)-2-((tert-butoxycarbonyl)amino)-3-(4-(1,1-difluoroethyl)phenyl)-3-hydroxypropyl)(5-(3-fluoro-6-isoquinolinyl)-1,3-thiazol-2-yl)carbamate

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Technology Process of tert-butyl ((2R,3S)-2-((tert-butoxycarbonyl)amino)-3-(4-(1,1-difluoroethyl)phenyl)-3-hydroxypropyl)(5-(3-fluoro-6-isoquinolinyl)-1,3-thiazol-2-yl)carbamate

There total 1 articles about tert-butyl ((2R,3S)-2-((tert-butoxycarbonyl)amino)-3-(4-(1,1-difluoroethyl)phenyl)-3-hydroxypropyl)(5-(3-fluoro-6-isoquinolinyl)-1,3-thiazol-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

tert-butyl ((2R,3S)-2-((tert-butoxycarbonyl)amino)-3-((tert-butyl(dimethyl)silyl)oxy)-3-(4-(1,1-difluoroethyl)phenyl)propyl)(5-(3-fluoro-6-isoquinolinyl)-1,3-thiazol-2-yl)carbamate (1236031-11-0) → tert-butyl ((2R,3S)-2-((tert-butoxycarbonyl)amino)-3-(4-(1,1-difluoroethyl)phenyl)-3-hydroxypropyl)(5-(3-fluoro-6-isoquinolinyl)-1,3-thiazol-2-yl)carbamate (1236031-12-1)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃;

Reference yield: 100.0%

tert-butyl ((2R,3S)-2-((tert-butoxycarbonyl)amino)-3-(4-(1,1-difluoroethyl)phenyl)-3-hydroxypropyl)(5-(3-fluoro-6-isoquinolinyl)-1,3-thiazol-2-yl)carbamate (1236031-12-1) + trifluoroacetic acid (76-05-1) → (1S,2R)-2-amino-1-(4-(1,1-difluoroethyl)phenyl)-3-((5-(3-fluoro-6-isoquinolinyl)-1,3-thiazol-2-yl)amino)-1-propanol trifluoroacetate (1236031-08-5)

Guidance literature:

In dichloromethane; at 20 ℃; for 0.25h;

upstream raw materials:

tert-butyl ((2R,3S)-2-((tert-butoxycarbonyl)amino)-3-((tert-butyl(dimethyl)silyl)oxy)-3-(4-(1,1-difluoroethyl)phenyl)propyl)(5-(3-fluoro-6-isoquinolinyl)-1,3-thiazol-2-yl)carbamate

Downstream raw materials:

(1S,2R)-2-amino-1-(4-(1,1-difluoroethyl)phenyl)-3-((5-(3-fluoro-6-isoquinolinyl)-1,3-thiazol-2-yl)amino)-1-propanol trifluoroacetate

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