4-{[(tetrahydro-2H-pyran-2-yloxy)methyl]pyridine-2,6-diyl}bis(methylene) bis(4-methylbenzenesulfonate)

Base Information

Chemical Name:4-{[(tetrahydro-2H-pyran-2-yloxy)methyl]pyridine-2,6-diyl}bis(methylene) bis(4-methylbenzenesulfonate)
CAS No.:1379456-68-4
Molecular Formula:C₂₇H₃₁NO₈S₂
Molecular Weight:561.677
Hs Code.:

Synonyms:4-{[(tetrahydro-2H-pyran-2-yloxy)methyl]pyridine-2,6-diyl}bis(methylene) bis(4-methylbenzenesulfonate)

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Chemical Property of 4-{[(tetrahydro-2H-pyran-2-yloxy)methyl]pyridine-2,6-diyl}bis(methylene) bis(4-methylbenzenesulfonate)

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Technology Process of 4-{[(tetrahydro-2H-pyran-2-yloxy)methyl]pyridine-2,6-diyl}bis(methylene) bis(4-methylbenzenesulfonate)

There total 4 articles about 4-{[(tetrahydro-2H-pyran-2-yloxy)methyl]pyridine-2,6-diyl}bis(methylene) bis(4-methylbenzenesulfonate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1379456-71-9
{4-[(tetrahydro-2H-pyran-2-yloxy)methyl]pyridine-2,6-diyl}dimethanol

: 98-59-9
p-toluenesulfonyl chloride

: 1379456-68-4
4-{[(tetrahydro-2H-pyran-2-yloxy)methyl]pyridine-2,6-diyl}bis(methylene) bis(4-methylbenzenesulfonate)

Guidance literature:: With potassium hydroxide; In dichloromethane; water; at 0 - 20 ℃; for 25h;
DOI:10.3998/ark.5550190.0013.513

Reference yield:

: 5453-67-8
2,6-bis(methoxycarbonyl)pyridine

: 1379456-68-4
4-{[(tetrahydro-2H-pyran-2-yloxy)methyl]pyridine-2,6-diyl}bis(methylene) bis(4-methylbenzenesulfonate)

Guidance literature:: Multi-step reaction with 4 steps

1.1: iron(II) perchlorate hexahydrate; dihydrogen peroxide; perchloric acid / water / 3 h / 0 - 20 °C

2.1: pyridinium p-toluenesulfonate; pyridine / dichloromethane / 25 h / 0 °C / Inert atmosphere; Reflux

3.1: sodium tetrahydroborate / ethanol / 26 h / 0 - 20 °C / Reflux

3.2: 1 h / Reflux

3.3: 1 h / Reflux

4.1: potassium hydroxide / water; dichloromethane / 25 h / 0 - 20 °C

With pyridine; sodium tetrahydroborate; perchloric acid; iron(II) perchlorate hexahydrate; dihydrogen peroxide; pyridinium p-toluenesulfonate; potassium hydroxide; In ethanol; dichloromethane; water; 1.1: |Fenton Reaction;
DOI:10.3998/ark.5550190.0013.513

Reference yield:

: 852936-60-8
dimethyl 4-(hydroxylmethyl)pyridine-2,6-dicarboxylate

: 1379456-68-4
4-{[(tetrahydro-2H-pyran-2-yloxy)methyl]pyridine-2,6-diyl}bis(methylene) bis(4-methylbenzenesulfonate)

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridinium p-toluenesulfonate; pyridine / dichloromethane / 25 h / 0 °C / Inert atmosphere; Reflux

2.1: sodium tetrahydroborate / ethanol / 26 h / 0 - 20 °C / Reflux

2.2: 1 h / Reflux

2.3: 1 h / Reflux

3.1: potassium hydroxide / water; dichloromethane / 25 h / 0 - 20 °C

With pyridine; sodium tetrahydroborate; pyridinium p-toluenesulfonate; potassium hydroxide; In ethanol; dichloromethane; water;
DOI:10.3998/ark.5550190.0013.513