Lithium 5-Methyl-cyclohexanone Enolate

Base Information

• Chemical Name: Lithium 5-Methyl-cyclohexanone Enolate
• CAS No.: 78782-00-0
• Molecular Formula: C₇H₁₁O*Li
• Molecular Weight: 118.105
• Mol file: 78782-00-0.mol

Synonyms:Lithium 5-Methyl-cyclohexanone Enolate

Chemical Property of Lithium 5-Methyl-cyclohexanone Enolate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of Lithium 5-Methyl-cyclohexanone Enolate

There total 1 articles about Lithium 5-Methyl-cyclohexanone Enolate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Trimethyl-(5-methyl-cyclohex-1-enyloxy)-silane (131671-65-3) → Lithium 5-Methyl-cyclohexanone Enolate (78782-00-0)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; at 25 ℃;

DOI:10.1021/jo00333a046

Reference yield:

Lithium 5-Methyl-cyclohexanone Enolate (78782-00-0) → isopulegone (29606-79-9)

Guidance literature:

Yield given. Multistep reaction. Yields of byproduct given;

DOI:10.1021/jo00333a046

Reference yield:

C5H5Fe(CO)2(CHCH3CHOC2H5)(1+)*BF4(1-) (75197-50-1) + Lithium 5-Methyl-cyclohexanone Enolate (78782-00-0) → p-menth-8-en-3-one (29606-79-9) + (+/-)-Isomenthone

Guidance literature:

C₅H₅Fe(CO)2(CHCH₃CHOC₂H₅)⁽¹⁺⁾*BF₄^(1-); Lithium 5-Methyl-cyclohexanone Enolate; In tetrahydrofuran; diethyl ether; at -78 ℃; for 1h; Inert atmosphere;

With boron trifluoride diethyl etherate; In tetrahydrofuran; at -78 ℃; for 0.5h; Inert atmosphere;

In acetonitrile; for 2h; Overall yield = 53 %; regiospecific reaction; Reflux; Inert atmosphere;

DOI:10.15227/orgsyn.066.0095

upstream raw materials:

Trimethyl-(5-methyl-cyclohex-1-enyloxy)-silane

Downstream raw materials:

isopulegone

p-menth-8-en-3-one