Technology Process of 2-[3'-cyano-4'-[phenylethynyl]phenyl]-1,3-diethyl-1,3,2-benzodiazaborole
There total 2 articles about 2-[3'-cyano-4'-[phenylethynyl]phenyl]-1,3-diethyl-1,3,2-benzodiazaborole which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
n-butyllithium;
In
tetrahydrofuran; hexane;
(Ar) to soln. arylbromide in THF at -110°C n-BuLi in hexane was added, stirred 20 min, soln. bromodiazaborole in THF was added and stirred at -110°C 4 h and at r.t. 16 h; soln. was evapd. to dryness, residue was suspended in n-hexane, heated to 60°C and filtered hot, volatiles were removed in vacuo, residue was crystd. from n-hexane at -35°C followed by crystn. from Et2O at -35°C; elem. anal.;
DOI:10.1039/c0dt01410a
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / Inert atmosphere
2.1: n-butyllithium / tetrahydrofuran; hexane / -110 °C / Inert atmosphere
2.2: -110 - 20 °C / Inert atmosphere
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; n-butyllithium; triethylamine;
In
tetrahydrofuran; hexane;
1.1: Sonogashira coupling;
DOI:10.1039/c0dt01410a
